26120-44-5

Basic information

• Product Name: 2-Methyl-4-nitro-2H-indazole
• Synonyms: 2-Methyl-4-nitro-2H-indazole;2-Methyl-4-nitroindazole;2-Methyl-4-nitro-1H-indazole;2H-Indazole, 2-methyl-4-nitro-
• CAS NO: 26120-44-5
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16
• Mol File: 26120-44-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 101-103 °C
• Boiling Point: 364.5°Cat760mmHg
• Flash Point: 174.2°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 3.51E-05mmHg at 25°C
• Refractive Index: 1.676
• Storage Temp.: 2-8°C
• PKA: -1.81±0.30(Predicted)
• CAS DataBase Reference: 2-Methyl-4-nitro-2H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-nitro-2H-indazole(26120-44-5)
• EPA Substance Registry System: 2-Methyl-4-nitro-2H-indazole(26120-44-5)

Safety Data

• Hazardous Substances Data: 26120-44-5(Hazardous Substances Data)

Usage

General Description

2-Methyl-4-nitro-2H-indazole is a chemical compound with the molecular formula C9H8N4O2. It is a yellow solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-Methyl-4-nitro-2H-indazole is also known for its use in the production of dyes and pigments. It is important to handle this substance with care as it is considered to be harmful if ingested or inhaled and may cause skin and eye irritation. Proper safety precautions should be taken when working with 2-Methyl-4-nitro-2H-indazole to minimize the risk of exposure.

InChI:InChI=1/C8H7N3O2/c1-10-5-6-7(9-10)3-2-4-8(6)11(12)13/h2-5H,1H3

Upstream product

• 77-78-1 dimethyl sulfate 
• 2942-40-7 nitro-4 indazole 
• 74-88-4 methyl iodide 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 603-83-8 3-nitro-o-tolylamine 
• 2533-69-9 methyl 2,2,2-trichloroacetimidate 

Downstream Products

• 82013-51-2 2-methyl-4-amino-2H-indazole 

Relevant articles and documents

New nitroindazolylacetonitriles: Efficient synthetic access: Via vicarious nucleophilic substitution and tautomeric switching mediated by anions

New N-Alkyl-nitroindazolylacetonitriles were efficiently obtained via vicarious nucleophilic substitution of N-methyl-nitroindazoles with 4-chlorophenoxyacetonitrile. All compounds were fully characterized by NMR and mass spectroscopy techniques and the structures of some of them were additionally confirmed by X-ray diffraction analysis data. Tautomeric switching was observed in this series of nitroindazolylacetonitriles upon addition of basic anions followed by UV-Vis spectrophotometric and 1H-NMR titrations. The formation of tautomeric species induced by anionic species was endorsed by Density Functional Theory calculations.

Regioselective methylation of indazoles using methyl 2,2,2- trichloromethylacetimidate

An efficient and regio selective synthesis of substituted 2-methyl-2H-indazoles using a methyl 2,2,2-trichloroacetimidate is described.

New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase

Taking into account the potency of 4- and 7-nitro and haloindazoles as nNOS inhibitors previously reported in the literature by our team, a multidisciplinary study, described in this article, has recently been carried out to elucidate their binding mode in the enzyme active site. Firstly, nitrogenous fastening points on the indazole building block have been investigated referring to molecular modeling hypotheses and thanks to the in vitro biological evaluation of N1- and N2-methyl and ethyl-4-substituted indazoles on nNOS. Secondly, we attempted to confirm the importance of the substitution in position 4 or 7 by a hydrogen bond acceptor group thanks to the synthesis and the in vitro biological evaluation of a new analogous 4-substituted derivative, the 4-cyanoindazole. Finally, by opposition to previous hypotheses describing NH function in position 1 of the indazole as a key fastening point, the present work speaks in favour of a crucial role of nitrogen in position 2.