82013-51-2

Basic information

• Product Name: 2-METHYL-2H-INDAZOL-4-YLAMINE
• Synonyms: 2-METHYL-2H-INDAZOL-4-YLAMINE;4-AMINO-2-METHYLINDAZOLE;2-Methyl-2H-indazole-4-amine;2-Methyl-2H-indazol-4-amine;4-Amino-2-methyl-2H-indazole 95%;4-Amino-2-methyl-2H-indazole95%;2-methylindazol-4-amine
• CAS NO: 82013-51-2
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.18
• Mol File: 82013-51-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 354.8°C at 760 mmHg
• Flash Point: 168.4°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 3.26E-05mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-METHYL-2H-INDAZOL-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2H-INDAZOL-4-YLAMINE(82013-51-2)
• EPA Substance Registry System: 2-METHYL-2H-INDAZOL-4-YLAMINE(82013-51-2)

Safety Data

• Hazardous Substances Data: 82013-51-2(Hazardous Substances Data)

Usage

Uses

2-Methyl-2H-indazol-4-ylamine is used as a reagent in organic synthesis including that of 4-(2-imidazolin-2-ylamino-2-methylindazole-HCl which display antihypertensive activity. It is also used in the synthesis of spleen tyrosine kinase (Syk) inhibitors that display high potency in the presence of blood.

InChI:InChI=1/C8H9N3/c1-11-5-6-7(9)3-2-4-8(6)10-11/h2-5H,9H2,1H3

Upstream product

• 77894-69-0 1-methyl-1H-indazol-4-ylamine 
• 26120-44-5 2-methyl-4-nitro-2H-indazole 
• 603-83-8 3-nitro-o-tolylamine 
• 2942-40-7 nitro-4 indazole 
• 26120-43-4 1-methyl-4-nitro-1H-indazole 

Relevant articles and documents

Reduction of nitroindazoles: Preparation of new amino and chloroamino derivatives

The synthesis of chloroaminoindazoles by the reduction of the nitro group of indazoles using stannous chloride in alcoholic acid solution is reported. Using catalytic hydrogenation with palladium the expected reduction to amino-indazoles occur.{A figure is presented}. Indazole Nitro Reduction Chlorination Aminochloroindazole Heterocycle.

HETEROAROMATIC UREAS WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I): are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).