26205-43-6Relevant articles and documents
Studies of the Synthesis of Tetronolide. Synthesis of a Spiro-α-acyltetronic Acid Model
Takeda, Kei,Shibata, Yumiko,Sagawa, Yukihiro,Urahata, Makoto,Funaki, Keishi,et al.
, p. 4673 - 4681 (1985)
The top half models 11 and 25 of the antibiotic aglycone tetronolide (1) were prepared from tetrahydrophthalide and 2,4-hexadiene-1,6-diol in 8 and 12 steps, respectively.Compound 11 was coupled with the bottom half model 30a, which was prepared via Diels-Alder reaction of methacrolein with triene 27a or 33a to afford α-acyltetronate 38.The allyl chloride 39 derived from 38 was rather unstable, and attempts for macrocyclization resulted in decomposition of the key intermediate.
Total synthesis of (-)- and (±)-frontalin via ring-closing metathesis
Scholl, Matthias,Grubbs, Robert H.
, p. 1425 - 1428 (2007/10/03)
Racemic and enantiopure targets containing the 6,8-dioxabicyclo [3.2.1]octane skeleton, can be conveniently synthesized from monocyclic diene precursors using an intramolecular ruthenium-catalyzed ring-closing metathesis reaction as the key step.
Synthesis of 2-Butenolide and Tetronic Acid Analogues of Thiolactomycin
Still, Ian W. J.,Drewery, Michael J.
, p. 290 - 295 (2007/10/02)
A synthetic route to the three lactone analogues 2a-c of the interesting antibiotic thiolactomycin (1a) is described.The synthetic strategy used is flexible in that it allows in principle for variation in the nature of the substituents introduced at C-2,
