263276-03-5

Basic information

• Product Name: N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester
• Synonyms: N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester
• CAS NO: 263276-03-5
• Molecular Weight: 482.364
• Mol File: 263276-03-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester(263276-03-5)
• EPA Substance Registry System: N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester(263276-03-5)

Safety Data

• Hazardous Substances Data: 263276-03-5(Hazardous Substances Data)

Upstream product

• 67630-01-7 (S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester 
• 229328-97-6 3,5-dichloroisonicotinoyl chloride 
• 67630-00-6 N-(tert-butyloxycarbonyl)-4-nitro-L-phenylalanine ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2457-47-8 3,5-dichloropyridine 
• 13958-93-5 3,5-dichloropyridine-4-carboxylic acid 

Downstream Products

• 913730-52-6 N-[N-Boc-4(R)-cyclobutylamino-(L)-prolyl]-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester 
• 913730-58-2 (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester 
• 913730-67-3 N-[N-(tert-butoxycarbonyl)-4(R)-3,3-dimethylpiperidino-(L)-prolyl]-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester 
• 913730-59-3 (S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride 
• 479667-30-6 (S)-3-{4-[(3,5-Dichloro-pyridine-4-carbonyl)-amino]-phenyl}-2-(4,6-dimethoxy-[1,3,5]triazin-2-ylamino)-propionic acid ethyl ester 
• 263276-28-4 N-isonicotinoyl-(L)-4-aminophenylalanine 

Relevant articles and documents

Squaric acid derivatives as VLA-4 integrin antagonists

SAR studies aimed at improving the rate of clearance by the incorporation of a 3,4-diamino-3-cyclobutene-1,2-dione group as an amino acid isostere in a series of VLA-4 integrin antagonists are described.

VLA-4 ANTAGONISTS

Substituted N-[N-(sulphonylphenyl)sulfonyl-prolyl]-phenylalanine derivatives of the present invention are antagonists of the VLA-4 integrin and are useful in the treatment, prevention and suppression of diseases mediated by VLA-4-binding and cell adhesion and activation. Moreover, the compounds of the present invention demonstrate significant receptor occupancy of VLA-4 bearing cells after oral administration and are suitable for once-, twice-, or thrice-a-day oral administration. This invention also relates to compositions containing such compounds and methods of treatment using such compounds.

PHENYLALANINE ENAMIDE DERIVATIVES CONTAINING A SPIRO`3.5!NON-1-ENE RING FOR USE AS INTEGRIN INHIBITORS

Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a -CH3, -(CH2)3CH3, -CH2CH20H, -CH2CH20CH3, -CH2CH2