913730-58-2

Basic information

• Product Name: (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester
• Synonyms: (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester
• CAS NO: 913730-58-2
• Molecular Weight: 633.572
• Mol File: 913730-58-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester(913730-58-2)
• EPA Substance Registry System: (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester(913730-58-2)

Safety Data

• Hazardous Substances Data: 913730-58-2(Hazardous Substances Data)

Upstream product

• 263276-03-5 N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester 
• 229328-97-6 3,5-dichloroisonicotinoyl chloride 
• 67630-00-6 N-(tert-butyloxycarbonyl)-4-nitro-L-phenylalanine ethyl ester 
• 67630-01-7 (S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester 
• 13958-93-5 3,5-dichloropyridine-4-carboxylic acid 

Downstream Products

• 913730-59-3 (S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride 

Relevant articles and documents

VLA-4 ANTAGONISTS

Substituted N-[N-(sulphonylphenyl)sulfonyl-prolyl]-phenylalanine derivatives of the present invention are antagonists of the VLA-4 integrin and are useful in the treatment, prevention and suppression of diseases mediated by VLA-4-binding and cell adhesion and activation. Moreover, the compounds of the present invention demonstrate significant receptor occupancy of VLA-4 bearing cells after oral administration and are suitable for once-, twice-, or thrice-a-day oral administration. This invention also relates to compositions containing such compounds and methods of treatment using such compounds.