26367-45-3Relevant articles and documents
Esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents
Jin, Guang-Zhu,You, Young-Jae,Ahn, Byung-Zun
, p. 1473 - 1476 (2001)
Eight esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone with melphalan were prepared and tested for their antitumor activity (S-180) and cytotoxicity. 2-{1-[4-(p-Bis(2-chloroethyl)-aminophenyl)-butanoyloxy]methyl}-1,4- dihydroxy-9,10-anthraquinone and 2-{1-[4-(p-bis(2-chloroethyl)-aminophenyl)-butanoyloxy]ethyl}-1,4-dihydroxy- 9,10-anthraquinone showed remarkable antitumor activity (T/C, 265 and 272%).