531-76-0

Basic information

• Product Name: Sarcolysinum
• Synonyms: Sarcolysinum;Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, DL- (8CI);DL-Phenylalanine mustard;DL-Phenylalanine, 4-[bis(2-chloroethyl)amino]-;DL-Sarcolysin;DL-Sarcolysine;Phenylalanine, 4-[bis(2-chloroethyl)amino]- (9CI);MERPHALAN
• CAS NO: 531-76-0
• Molecular Formula: C₁₃H₁₈Cl₂N₂O₂
• Molecular Weight: 305.23
• Mol File: 531-76-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 180.5°C
• Boiling Point: 473.1°Cat760mmHg
• Flash Point: 239.9°C
• Appearance: /
• Density: 1.3587 (rough estimate)
• Refractive Index: 1.6070 (estimate)
• Storage Temp.: 2-8°C
• PKA: 2.12±0.10(Predicted)
• CAS DataBase Reference: Sarcolysinum(CAS DataBase Reference)
• NIST Chemistry Reference: Sarcolysinum(531-76-0)
• EPA Substance Registry System: Sarcolysinum(531-76-0)

Safety Data

• Hazardous Substances Data: 531-76-0(Hazardous Substances Data)

Usage

General Description

Tiny needles (from methanol).

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for Sarcolysinum are not available. Sarcolysinum is probably combustible.

Safety Profile

Suspected carcinogen withexperimental tumorigenic data. A poison by ingestion,intraperitoneal, intravenous, and intracerebral routes. Anexperimental teratogen. Other experimental reproductiveeffects. Mutation data reported. An antineoplastic agent.Wh

InChI:InChI=1/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)

Upstream product

• 75-21-8 oxirane 
• 68199-91-7 4-amino-N-benzoyl-DL-phenylalanine ethyl ester 
• 13057-62-0 acetylamino-{4-[bis-(2-hydroxy-ethyl)-amino]-benzyl}-malonic acid diethyl ester 
• 98844-19-0 4-amino-N,N-phthaloyl-DL-phenylalanin-ethyl ester 
• 90102-87-7 methyl α-benzamido-4-phenylalaninate 
• 90102-86-6 methyl α-benzamido-4-cinnamate 
• 90897-97-5 4-<4-benzylidene>2-phenyl-2-oxazolin-5-one 
• 83772-59-2 4-<4-benzylidene>-4'-N,N-dimethylaminoaniline 
• 6265-87-8 2-acetylamino-2-(4-nitrobenzyl)malonic acid diethyl ester 
• 6335-21-3 diethyl 2-acetamido-2-(4-aminobenzyl)malonate 

Downstream Products

• 87507-73-1 4-[bis-(2-chloro-ethyl)-amino]-phenylalanine isopropyl ester 
• 5786-56-1 N-acetyl-4-[bis(2-chloroethyl)amino]-DL-phenylalanine 
• 102881-57-2 4-{4-[bis-(2-chloro-ethyl)-amino]-benzylidene}-2-methyl-4H-oxazol-5-one 
• 19509-45-6 4-{4-[bis-(2-chloro-ethyl)-amino]-benzyl}-oxazolidine-2,5-dione 
• 60557-39-3 N-(phenylacetyl)melphalan 
• 23583-14-4 NPS-Sarcolysin 
• 61733-01-5 Monohydroxymelphalan 
• 26367-45-3 N-formylsarcolysine 
• 103757-56-8 N^α-{4-[bis-(2-chloro-ethyl)-amino]-N-formyl-phenylalanyl}-tryptophan-methyl ester 
• 23578-99-6 Sarc-Gly 
• 23578-98-5 Sarc-β-Ala 
• 47503-12-8 Sarc-β-Ala-OEt 
• 23578-97-4 NPS-Sarc-β-Ala-OEt 
• 23578-91-8 NPS-Sarc-Gly-OBzh 

Relevant articles and documents

Release of Amino- or Carboxy-Containing Compounds Triggered by HOCl: Application for Imaging and Drug Design

The overproduction of HOCl is highly correlated with diseases such as atherosclerosis, rheumatoid arthritis, and cancer. Whilst acting as a marker of these diseases, HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease. In this work, a new platform of HOCl probes has been developed that integrates detection, imaging, and therapeutic functions. The probes can detect HOCl, using both NIR emission and the naked eye in vitro, with high sensitivity and selectivity at ultralow concentrations (the detection limit is at the nanomolar level). Basal levels of HOCl can be imaged in HL-60 cells without special stimulation. Moreover, the probes provided by this platform can rapidly release either amino- or carboxy-containing compounds from prodrugs, during HOCl detection and imaging, to realize a therapeutic effect.