263711-74-6 Usage
Description
Apigenin-D5, a deuterated form of apigenin, is a flavonoid compound commonly found in various fruits and vegetables. It serves as an internal standard for the quantification of apigenin using gas chromatography (GC) or liquid chromatography (LC) coupled with mass spectrometry (MS). Apigenin-D5 exhibits pale yellow crystalline solid properties and is known for its ability to selectively inhibit casein kinase 2 (CK2), which plays a role in various cellular processes.
Uses
Used in Pharmaceutical Applications:
Apigenin-D5 is used as an internal standard for the quantification of apigenin in pharmaceutical research. This application is crucial for ensuring accurate and reliable measurements of apigenin levels in various samples, such as biological tissues, fluids, and pharmaceutical formulations.
Used in Research and Development:
Apigenin-D5 is used as a research tool in the study of CK2 inhibition and its potential therapeutic applications. By inhibiting CK2 activity, apigenin has demonstrated the ability to improve renal function in a rat model of glomerulonephritis, decrease the degradation of IκBα, down-regulate NF-κB levels in WEHI-231 cells, and inhibit the synthesis of inflammatory mediators nitric oxide and prostaglandin E2.
Used in Analytical Chemistry:
Apigenin-D5 is employed as a reference compound in the development and validation of analytical methods for the determination of apigenin in complex matrices. Its use as an internal standard helps to correct for any variations in sample preparation, instrumental response, and other factors that may affect the accuracy of the measurements.
Used in Quality Control:
Apigenin-D5 is utilized in the quality control of pharmaceutical products containing apigenin or its derivatives. By comparing the response of the sample to that of the internal standard, it is possible to ensure the consistency, purity, and potency of the active ingredient in the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 263711-74-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,3,7,1 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 263711-74:
(8*2)+(7*6)+(6*3)+(5*7)+(4*1)+(3*1)+(2*7)+(1*4)=136
136 % 10 = 6
So 263711-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H/i3D,4D,5D,6D,7D
263711-74-6Relevant articles and documents
Synthesis of deuterium labeled polyhydroxy flavones and 3-flavonols
Rasku, Sirpa,W?h?l?, Kristiina
, p. 913 - 916 (2000)
Syntheses are described for seven new deuterium labeled flavones, [3,6,8,3',5'-D5]-apigenin 5, [3,3',5'-D3]-apigenin 6, [3,6,8,2',5',6'-D6]- luteolin 7, [3,2',5',6'-D4]-luteolin 8, [6,8,2',5',6'-D5]-q
