26391-06-0 Usage
Description
2-Cyano-N,N-diethylacetamide is an organic compound with the chemical formula C7H12N2. It is a pale brown oil at room temperature and is known for its versatile applications in the synthesis of various compounds and as a building block in the development of new materials.
Uses
Used in Pharmaceutical Synthesis:
2-Cyano-N,N-diethylacetamide is used as an intermediate in the synthesis of N,N-diethyl 2-cyano-2-fluoro-2-phenylthioacetoamide, which is further utilized in the production of various cyanofluoroamides. These cyanofluoroamides have potential applications in the pharmaceutical industry, particularly in the development of new drugs.
Used in Entacapone Production:
In the pharmaceutical industry, 2-Cyano-N,N-diethylacetamide is also used in the synthesis of entacapone, a catechol-O-methyltransferase inhibitor. Entacapone is an essential drug used in the treatment of Parkinson's disease, and its production involves reacting 2-Cyano-N,N-diethylacetamide with 3,4-dihydroxy-5-nitrobenzaldehyde.
Used in Fluorophore Synthesis:
2-Cyano-N,N-diethylacetamide serves as a building block in the synthesis of fluorophores, which are essential for various applications in the field of biochemistry and molecular biology. Specifically, it is used in the development of endoplasmic reticulum probes, which are crucial for studying the structure and function of the endoplasmic reticulum in cells.
Check Digit Verification of cas no
The CAS Registry Mumber 26391-06-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,3,9 and 1 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 26391-06:
(7*2)+(6*6)+(5*3)+(4*9)+(3*1)+(2*0)+(1*6)=110
110 % 10 = 0
So 26391-06-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H12N2O/c1-3-9(4-2)7(10)5-6-8/h3-5H2,1-2H3
26391-06-0Relevant articles and documents
Synthesis and Docking Study of Novel Pyranocoumarin Derivatives
Karteek, S. Durga,Reddy, A. Gopi,Tej, M. Bhuvan,Rao, M. V. Basaveswara
, p. 272 - 282 (2021/04/02)
Abstract: A new series of fused tricyclic coumarin derivatives were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by molecular docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compounds.
A light-up endoplasmic reticulum probe based on a rational design of red-emissive fluorogens with aggregation-induced emission
Zhang, Chong-Jing,Cai, Xiaolei,Xu, Shidang,Zhan, Ruoyu,Jien, Wu,Liu, Bin
supporting information, p. 10792 - 10795 (2017/10/06)
Fine-tuning electron acceptors through changing one cyano group to an amide generates a more stable and emissive fluorophore with the character of aggregation-induced emission. Conjugation between the new fluorophore and CFFKDEL generated an excellent ER targeting light-up probe with high specificity and good photostability.
Synthesis of new 8-formyl-4-methyl-7-hydroxy coumarin derivatives
Manidhar,Rao, K. Uma Maheswara,Reddy, N. Bakthavatchala,Sundar, Ch. Syama,Reddy, C. Suresh
, p. 459 - 463 (2012/11/07)
8-Formyl-4-Methyl-7-Hydroxy Coumarin Derivatives were synthesized via Penchem condensation followed by Duffs reaction. Treatment of this with N,N-di substituted cyano acetamides in the presence of piperdine afforded New 8- Formyl-4-Methyl-7-Hydroxy Coumarin Derivatives (7a-o). Their structures were characterized by IR, 1H and 13C NMR and Mass spectral and elemental analysis data.
