857629-79-9 Usage
Description
(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a chemical compound that serves as an impurity in Entacapone (E558500), a medication used for the treatment of Parkinson's disease. It is a derivative of the 2-propenamide class, characterized by the presence of a cyano group, an ethoxy-substituted hydroxyl group, and a nitro group on the phenyl ring. (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide plays a role in the pharmaceutical industry due to its association with Entacapone.
Uses
Used in Pharmaceutical Industry:
(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is used as an impurity in Entacapone, a medication that acts as a peripherally acting inhibitor of catechol-O-methyl transferase (COMT). This enzyme is involved in the metabolism of catecholamine neurotransmitters and related drugs, making Entacapone a valuable treatment for Parkinson's disease. The presence of this compound in Entacapone is significant for understanding the drug's composition and ensuring its safety and efficacy in antiparkinsonian applications.
Check Digit Verification of cas no
The CAS Registry Mumber 857629-79-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,7,6,2 and 9 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 857629-79:
(8*8)+(7*5)+(6*7)+(5*6)+(4*2)+(3*9)+(2*7)+(1*9)=229
229 % 10 = 9
So 857629-79-9 is a valid CAS Registry Number.
857629-79-9Relevant articles and documents
IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE
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Page/Page column 6-7, (2008/06/13)
The invention disclosed in this application relates to an improved process for the preparation of the Entacapone which comprises. (i)reacting 3-alkoxy- 4-hydroxy-5-nitrobenzadehyde with N,N-diethylaminocyanoactamide in the presence of mild acid catalyst and a solvent at a temperature in the range of 50-115 °C, to get the 3-O-alkylated (methyl or ethyl) Entacapone and treating with acid catalysts in the presence of organic base and solvents at temperature in the range of 20-60 °C to get Entacapone.
