26561-15-9

Basic information

• Product Name: 4,5,3',4'-tetramethoxy-2-propyl-benzophenone
• Synonyms: 4,5,3',4'-tetramethoxy-2-propyl-benzophenone
• CAS NO: 26561-15-9
• Molecular Weight: 344.408
• Mol File: 26561-15-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4,5,3',4'-tetramethoxy-2-propyl-benzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,3',4'-tetramethoxy-2-propyl-benzophenone(26561-15-9)
• EPA Substance Registry System: 4,5,3',4'-tetramethoxy-2-propyl-benzophenone(26561-15-9)

Safety Data

• Hazardous Substances Data: 26561-15-9(Hazardous Substances Data)

Upstream product

• 5888-52-8 4-propyl-1,2-dimethoxybenzene 
• 93-07-2 Veratric acid 
• 2785-87-7 2-methoxy-4-n-propylphenol 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 77-78-1 dimethyl sulfate 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 

Downstream Products

• 22345-47-7 tofisopam 
• 26561-17-1 1-(3,4-Dimethoxy-phenyl)-1-(3,4-dimethoxy-6-propyl-phenyl)-propan 
• 26561-16-0 1-(3,4-Dimethoxy-phenyl)-1-(3,4-dimethoxy-6-propyl-phenyl)-1-propanol 
• 41565-05-3 4,5-dimethoxy-2-veratroyl-benzoic acid methyl ester 
• 102719-50-6 2-(3,4-dimethoxybenzoyl)-4,5-dimethoxypropiophenone 

Relevant articles and documents

Synthesis of Tofisopam by Way of Photoinduced CO2 Fixation

Herein reported is a unique synthetic route of Tofisopam, an anxiolytic drug containing a 2,3-benzodiazepine core structure. 3,4-Dimethoxypropylbenzene and 3,4-dimethoxybenzoic acid, which are both of plant origin, and CO2 constitute its carbon skeleton. These three renewable substances are united by two C?C bond forming reactions, i.e., a Friedel–Crafts acylation reaction and a photoinduced carboxylation reaction to construct the major carbon framework. Finally, a methyl group is introduced by a Kumada-type cross-coupling reaction to furnish Tofisopam. Various analogs of Tofisopam are readily synthesized by introducing other substituents than a methyl group at the last C?C bond forming step.