267401-33-2

Basic information

• Product Name: (R)-2-acetaMido-2-(2-fluorophenyl)propanoic acid
• Synonyms: (R)-2-acetaMido-2-(2-fluorophenyl)propanoic acid;(R)-(-)-N-acetyl-alpha-(2-fluorophenyl)-alpha-methylglycine;Benzeneacetic acid, α-(acetylamino)-2-fluoro-α-methyl-, (αR)-
• CAS NO: 267401-33-2
• Molecular Formula: C₁₁H₁₂FNO₃
• Molecular Weight: 225.2162832
• Mol File: 267401-33-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-2-acetaMido-2-(2-fluorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-acetaMido-2-(2-fluorophenyl)propanoic acid(267401-33-2)
• EPA Substance Registry System: (R)-2-acetaMido-2-(2-fluorophenyl)propanoic acid(267401-33-2)

Safety Data

• Hazardous Substances Data: 267401-33-2(Hazardous Substances Data)

Usage

General Description

(R)-2-Acetamido-2-(2-fluorophenyl)propanoic acid is a chemical compound that consists of a propanoic acid with a 2-fluorophenyl group and an acetamido group attached to the second carbon atom. It is a chiral compound, meaning it has a specific spatial arrangement of atoms. (R)-2-Acetamido-2-(2-fluorophenyl)propanoic acid is commonly used as a starting material in the synthesis of pharmaceuticals and other organic compounds. Its properties and reactivity make it useful for a variety of applications in the chemical industry.

Upstream product

• 267401-31-0 N-acetyl-α-(2-fluorophenyl)-α-methylglycine 
• 445-27-2 2'-Fluoroacetophenone 
• 320-58-1 (RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid 
• 7248-25-1 (RS)-5-(2-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione 

Relevant articles and documents

Water soluble phosphines: Part XIII. Chiral phosphine ligands with amino acid moieties

Nucleophilic phosphination of the potassium or sodium salt of the fluorophenylalanines (1a, 2a) or -glycines (3a, 4a) with potassium phosphides Ph(R)PK (R=Me, Ph) yields chiral phosphine ligands (1-7) with amino acid moieties. The X-ray structure of 3·2H2O (space group Pbca) has been determined showing a betaine type structure for the amino acid moiety. The α-methyl derivatives of the phosphinophenylglycines (10, 11) were obtained in an analogous manner as 1-7. ortho- and para-Fluoroacetophenones have been employed as starting material for the syntheses of α-[4-fluorophenyl]-α-methylglycine (9c) and its ortho-isomer (8c), the X-ray structure of its monohydrate has been determined (space group P1?). The N-acetyl (3b, 8e) and ester derivatives (3d, 8d) of 3 and 8c are accessible using standard procedures. Resolution of the diastereomeric salt 12 obtained from (S)-(+)-2-hydroxymethylpyrrolidine and racem-8e by fractionated crystallization yielded the (S,R)-isomer. The absolute configuration of (S,R)-12 was determined by X-ray structural analysis (space group P212121). Cleavage of (S,R)-12 with hydrochloric acid gave enantiopure (R)-8e [α]D20=-30.9° (c=1, CH3OH).