268737-90-2Relevant articles and documents
Solid-phase synthesis of carbocyclic nucleosides.
Crimmins,Zuercher
, p. 1065 - 1067 (2007/10/03)
[formula: see text] An efficient solid-phase synthesis of carbocyclic nucleosides has been developed. The key step is the palladium-catalyzed coupling of a purine derivative to a resin-bound allylic benzoate. The resulting products may be further functionalized on the solid phase. Acidic cleavage affords carbocyclic nucleosides, a class of compounds with demonstrated biological activity and substantial current interest.