2689-81-8

Basic information

• Product Name: Phosphonium, [2-(4-chlorophenyl)-2-oxoethyl]triphenyl-, bromide
• CAS NO: 2689-81-8
• Molecular Formula: C26H21ClOP.Br
• Molecular Weight: 495.783
• Mol File: 2689-81-8.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Phosphonium, [2-(4-chlorophenyl)-2-oxoethyl]triphenyl-, bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonium, [2-(4-chlorophenyl)-2-oxoethyl]triphenyl-, bromide(2689-81-8)
• EPA Substance Registry System: Phosphonium, [2-(4-chlorophenyl)-2-oxoethyl]triphenyl-, bromide(2689-81-8)

Safety Data

• Hazardous Substances Data: 2689-81-8(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 128256-29-1 C₁₄H₁₂BrClN₂O₂S 
• 1777-56-6 4-chlorobenzoylmethylenetriphenylphosphorane 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 603-35-0 triphenylphosphine 

Downstream Products

• 1256284-91-9 1-(4-chlorophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone 
• 1435944-23-2 tert-butyl 2-(4-chlorobenzoyl)indoline-1-carboxylate 
• 1435944-12-9 tert-butyl 2-(3-(4-chlorophenyl)-3-oxopropyl)phenylcarbamate 
• 1422452-66-1 (E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one 
• 1422452-54-7 (E)-3-(3-(4-chlorophenyl)-3-oxoprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one 
• 1245905-87-6 (E)-1-(4-chlorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one 
• 866206-04-4 1-(4-chlorophenyl)-4-trifluoro-2-triphenylphosphranyliden-1,3-butanedione 
• 29582-39-6 3-(4-chlorobenzoyl)acrylic acid 
• 89781-40-8 C₁₂H₁₁ClO₃ 
• 328527-00-0 2-amino-4-cyclohexyl-6-(4-dimethylamino-phenyl)-nicotinonitrile 
• 328526-99-4 2-amino-4-butyl-6-(4-dimethylamino-phenyl)-nicotinonitrile 

Relevant articles and documents

Substituent effects in the formation of a few acenaphthenone-2-ylidene ketones and their molecular docking studies and in silico ADME profile

We observed intriguing substituent effects in the reaction between 4-substituted acetophenones and acenaphthenequinone in the presence of KOH in methanol. In all cases, expected Claisen-Schimdt condensation was the first step. However, depending on the nature of 4-substituent on acetophenone, the initially formed condensation product remain unchanged or underwent Domino sequence of reactions to give three different 2:2 adducts arising through three distinct pathways. The interactions of acenaphthenone-2-ylidene ketones with the target proteins were performed by molecular docking studies. The prediction of in silico ADME belongings of the synthesized compounds revealed substantial drug-likeness characters based on Lipinski's rules.

Rh(iii)-catalyzed diastereoselective cascade annulation of enone-tethered cyclohexadienonesviaC(sp2)-H bond activation

Herein, we report highly diastereoselective arylative cyclization of enone-tethered cyclohexadienonesviaRh(iii)-catalyzed C-H activation ofN-methoxybenzamides. This reaction proceeds through the formation of a five-membered rhodacycle followed by bis-Michael cascade annulation to access functionalized bicyclic scaffolds with four contiguous stereocenters with a broad substrate scope. These products have excellent functional handles, allowing further synthetic transformation to increase the structural complexity. Furthermore, mechanistic studies of arylative cyclization and a gram-scale experiment are also presented.

PYRROLIDINE DERIVATIVES AS PPAR AGONISTS

The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholgangitis, dyslipidenmia, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, cardiovascular disease, obesity or the like). In particular, the present invention discloses a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.