26961-99-9Relevant articles and documents
Nickel-catalyzed carboxylation of aryl and vinyl chlorides employing carbon dioxide
Fujihara, Tetsuaki,Nogi, Keisuke,Xu, Tinghua,Terao, Jun,Tsuji, Yasushi
supporting information; experimental part, p. 9106 - 9109 (2012/07/13)
Nickel-catalyzed carboxylation of aryl and vinyl chlorides employing carbon dioxide has been developed. The reactions proceeded under a CO2 pressure of 1 atm at room temperature in the presence of nickel catalysts and Mn powder as a reducing agent. Various aryl chlorides could be converted to the corresponding carboxylic acid in good to high yields. Furthermore, vinyl chlorides were successfully carboxylated with CO2. Mechanistic study suggests that Ni(I) species is involved in the catalytic cycle.
Heteroatom substituted propanyl derivatives having 5-lipoxygenase inhibitory activity
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, (2008/06/13)
Compounds of the structure STR1 where R1 is alkyl of one to four carbon atoms and R2 is selected from (a) alkenyl of one to four carbon atoms, (b) STR2 (c) STR3 and (d) STR4 are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
((4-ALKOXYPYRAN-4-YL) SUBSTITUTED) ETHER, ARYLALKYL-, ARYLALKENYL-, AND ARYLALKYNYL)UREA INHIBITORS OF 5-LIPOXYGENASE
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, (2008/06/13)
Compounds of the structure where W is selected from where Q is oxygen or sulfur, R6and R7 are hydrogen or alkyl, or R6 and R7 , together with the nitrogen atoms to which they are attached, define a radical of formula Z is -CH2-, oxygen, sulfur, or -NR9,