270929-33-4

Basic information

• Product Name: benzyl-(2,6-dichloro-pyrimidin-4-yl)-carbamic acid tert-butyl ester
• Synonyms: benzyl-(2,6-dichloro-pyrimidin-4-yl)-carbamic acid tert-butyl ester
• CAS NO: 270929-33-4
• Molecular Weight: 354.236
• Mol File: 270929-33-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl-(2,6-dichloro-pyrimidin-4-yl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl-(2,6-dichloro-pyrimidin-4-yl)-carbamic acid tert-butyl ester(270929-33-4)
• EPA Substance Registry System: benzyl-(2,6-dichloro-pyrimidin-4-yl)-carbamic acid tert-butyl ester(270929-33-4)

Safety Data

• Hazardous Substances Data: 270929-33-4(Hazardous Substances Data)

Upstream product

• 3764-01-0 2,4,6-trichloropyrimidine 
• 42116-44-9 N-tert-butoxycarbonylbenzylamine 

Downstream Products

• 1067679-38-2 benzyl-(2-chloro-6-(2-naphthalen-1-yl-ethyl)-pyrimidin-4-yl)-carbamic acid tert-butyl ester 
• 1067679-65-5 benzyl-(6-chloro-2-(3-methyl-butyl)-pyrimidin-4-yl)-carbamic acid tert-butyl ester 
• 1067679-35-9 benzyl-(2-chloro-6-(3-methyl-butyl)-pyrimidin-4-yl)-carbamic acid tert-butyl ester 
• 90042-88-9 4-benzilamino-2,6-tricloropirimidina 

Relevant articles and documents

Regioselective 4-amino-de-chlorination of trichloro- and dichloro-pyrimidines with N-sodium carbamates

4-N-Alkoxycarbonylamino-2,6-dichloro- and -2-chloro-pyrimidines have been synthesized in good to excellent regioselectivity and yields from N-sodium carbamates and, respectively, 2,4,6-trichloropyrimidine and 2,4-dichloropyrimidine, in DMF, rt, 15-30 min. The reaction is effective also with 4,6-dichloropyrimidine, producing 4-N-alkoxycarbonylamino-6-chloropyrimidines in good yields. Some conformational features of 4-N-alkoxycarbonylamino-2,6-dichloro-pyrimidines have been investigated by X-ray diffraction and 1H NMR spectroscopy.

Efficient and regioselective 4-amino-de-chlorination of 2,4,6- trichloropyrimidine with N-sodium carbamates

4-N-Alkoxycarbonyl-2,6-dichloropyrimidines have been synthesized with good to excellent regioselectivity and yields from 2,4,6-trichloropyrimidine and N-sodium carbamates in DMF, at room temperature, in 15-30 minutes. (C) 2000 Elsevier Science Ltd.