275812-32-3 Usage
General Description
CCR3 antagonist refers to a class of chemicals that inhibit the function of the C-C chemokine receptor type 3 (CCR3), a protein involved in immune and inflammatory responses. These antagonists work by blocking the binding of specific chemokines to the CCR3 receptor, thereby preventing the activation and migration of certain immune cells, such as eosinophils and basophils, that are involved in allergic and inflammatory diseases. By inhibiting CCR3, these chemicals have the potential to reduce inflammation and tissue damage associated with conditions such as asthma, allergic rhinitis, and atopic dermatitis. Therefore, CCR3 antagonists are being researched and developed as potential treatments for these and other diseases characterized by excessive immune responses.
Check Digit Verification of cas no
The CAS Registry Mumber 275812-32-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,5,8,1 and 2 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 275812-32:
(8*2)+(7*7)+(6*5)+(5*8)+(4*1)+(3*2)+(2*3)+(1*2)=153
153 % 10 = 3
So 275812-32-3 is a valid CAS Registry Number.
275812-32-3Relevant articles and documents
Stereoselective process for a CCR3 antagonist
Yue, Tai-Yuen,McLeod, Douglas D.,Albertson, Kevin B.,Beck, Steven R.,Deerberg, Joerg,Fortunak, Joseph M.,Nugent, William A.,Radesca, Lilian A.,Tang, Liya,Xiang, Cathie Dong
, p. 262 - 271 (2012/12/22)
A convergent, multikilogram, stereoselective synthesis of 1 is described. A key fragment, (S)-3-(4-fluorobenzyl)piperidine (2) was synthesized from valerolactam in three steps using our recently discovered Ir-BDPP-catalyzed asymmetric hydrogenation. Anoth
