275826-46-5

Basic information

• Product Name: (S)-3-AMINO-3-(1-NAPHTHYL)-PROPIONIC ACID
• Synonyms: H-BETA-ALA-(1-NAPHTHYL)-OH;H-D-NPG(1)-(C*CH2)OH;H-D-GLY(1-NAPH)-(C*CH2)OH;(S)-3-AMINO-3-NAPHTHALEN-1-YL-PROPIONIC ACID;(S)-3-AMINO-3-(1-NAPHTHYL)-PROPIONIC ACID;H-b-Ala-(1-naphthyl)-OH;(S)- 3-Amino-3-(1-naphthylphenyl)-propionic acid;(S)-3-amino-3-(naphthalen-1-yl)propanoic acid
• CAS NO: 275826-46-5
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.25
• Mol File: 275826-46-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 227-229 °C
• Boiling Point: 412.3 °C at 760 mmHg
• Flash Point: 203.2 °C
• Appearance: /
• Density: 1.252 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.41±0.12(Predicted)
• CAS DataBase Reference: (S)-3-AMINO-3-(1-NAPHTHYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-AMINO-3-(1-NAPHTHYL)-PROPIONIC ACID(275826-46-5)
• EPA Substance Registry System: (S)-3-AMINO-3-(1-NAPHTHYL)-PROPIONIC ACID(275826-46-5)

Safety Data

• Hazardous Substances Data: 275826-46-5(Hazardous Substances Data)

Usage

General Description

(S)-3-AMINO-3-(1-NAPHTHYL)-PROPIONIC ACID is a chemical compound that belongs to the class of amino acids and derivatives. It is a derivative of phenylalanine and is commonly used in the synthesis of peptides and pharmaceuticals. (S)-3-AMINO-3-(1-NAPHTHYL)-PROPIONIC ACID is a chiral molecule, meaning it has different spatial arrangements of atoms that give it distinct properties. It is used in the development of drugs for the treatment of various diseases, including neurological disorders and cancer. Additionally, it has potential applications in the field of materials science due to its unique structural and chemical properties. Overall, (S)-3-AMINO-3-(1-NAPHTHYL)-PROPIONIC ACID is an important chemical with diverse uses and potential applications in various fields.

Upstream product

• 141-82-2 malonic acid 
• 66-77-3 1-naphthaldehyde 
• 275826-33-0 3-amino-3-(1-naphthyl)propionic acid ethyl ester 
• 100393-41-7 3-amino-3-(1-naphthyl)propionic acid 

Downstream Products

• 275826-46-5 (S)-3-amino-3-(1-naphthyl)propionic acid 

Relevant articles and documents

Ruthenium-catalyzed asymmetric epoxidation of olefins using H 2O2, part I: Synthesis of new chiral N,N,N,-tridentate pybox and pyboxazine ligands and their ruthenium complexes

The synthesis of chiral tridentate N,N,N-pyridine-2.6-bisoxazolines 3 (pyhox ligands) and N,N,N-pyridine-2.6-bisoxazines 4 (pyboxazine ligands) is described in detail. These novel ligands constitute a useful tool-box for the application in asymmetric catalysis. Compounds 3 and 4 are conveniently prepared by cyclization of enantiomerically pure α- or β-amino al cohols with dimethyl pyridine-2,6-dicarboximidate. The corresponding ruthenium complexes are efficient asymmetric epoxidation catalysts and have been prepared in good yield and fully char acterized by spectroscopic means. Four of these ruthenium complexes have been characterized by X-ray crystallography. For the first time the molecular structure of a pyboxazine complex (2,6-bis-[(4S)-4-phenyl-5,6- dihydro-4H-[1,3]oxazinyl]pyridine)(pyridine-2,6-dicarboxylate)ruthenium (S)-2aa, is presented.

SYNTHESIS OF 6-ARYL-4-HYDROXYPIPERIDIN-2-ONES AND A POSSIBLE APPLICATION TO THE SYNTHESIS OF A NOVEL HMG-CoA REDUCTASE INHIBITOR

A series of 6-aryl-4-hydroxypiperidin-2-ones (11a-11g) were synthesised with the key step being a Dieckmann cyclisation of the appropriate methyl 3-(ethoxycarbonylacetylamino)-3-(substituted) propionate (8a-8g) and this new synthetic route was successfully applied to the synthesis of 4-hydroxy-6-(2-phenylethyl)piperidin-2-one (11h).The application of this strategy to the synthesis of the putative HMG-CoA reductase inhibitor 6--4-hydroxypiperidin-2-one (11i) was attempted, but failed during the Dieckmann cyclisation of methyl 3-(ethoxycarbonylacetylamino)- 3-propionate (8i).An alternative synthesis of a 1:1 diastereomeric mixture of (11i) was achieved by the reductive cleavage of the isoxazoline (24) with Raney nickel.The mixture of diastereoisomers (11i) was inactive in-vitro and in-vivo (rat) against HMG-CoA reductase