27610-14-6 Usage
Description
3-amino-6-chloro-3,4-dihydro-4-phenylquinazolin-4-ol is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes an amino group, a chloro substituent, and a phenyl ring attached to a quinazolinol backbone.
Uses
Used in Pharmaceutical Synthesis:
3-amino-6-chloro-3,4-dihydro-4-phenylquinazolin-4-ol is used as an intermediate in the synthesis of 1-Chloroacetyl-2-[[(2-benzoyl-4-chlorophenyl)(2-chloroacetyl)amino]methylene]hydrazide (C363470). 3-amino-6-chloro-3,4-dihydro-4-phenylquinazolin-4-ol is a derivative of 2-Amino-5-chlorobenzophenone (A603490), which is a metabolite of Diazepam (D416855). The intermediate plays a vital role in the development of pharmaceuticals with potentially weaker anticonvulsant effects compared to Diazepam, offering an alternative for patients who may require different treatment options.
Used in Drug Metabolism Research:
As a metabolite of Diazepam, 3-amino-6-chloro-3,4-dihydro-4-phenylquinazolin-4-ol can be utilized in research to understand the metabolic pathways and pharmacokinetics of Diazepam and its related compounds. This knowledge can contribute to the development of more effective anticonvulsant medications and inform dosing strategies for patients.
Used in Chemical Synthesis for Other Applications:
The unique structure of 3-amino-6-chloro-3,4-dihydro-4-phenylquinazolin-4-ol also makes it a potential candidate for use in the synthesis of other chemical compounds beyond the pharmaceutical industry. Its versatility in chemical reactions may lead to applications in various fields, such as materials science, agrochemistry, or environmental chemistry, where novel compounds with specific properties are sought after.
Check Digit Verification of cas no
The CAS Registry Mumber 27610-14-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,6,1 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 27610-14:
(7*2)+(6*7)+(5*6)+(4*1)+(3*0)+(2*1)+(1*4)=96
96 % 10 = 6
So 27610-14-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H12ClN3O/c15-11-6-7-13-12(8-11)14(19,18(16)9-17-13)10-4-2-1-3-5-10/h1-9,19H,16H2
27610-14-6Relevant articles and documents
Preparation method of 6-chloro-3-amino-3,4-dihydro-4-hydroxyl-4-phenyl quinazoline
-
Paragraph 0014; 0015; 0016, (2018/03/26)
The invention provides a preparation method of 6-chloro-3-amino-3,4-dihydro-4-hydroxyl-4-phenyl quinazoline. 5-chloro-2-aminoben-zophenone is fed into a mixed solvent; after dimethylformamide is added, phosphorus oxychloride is dropwise added; after formamidine reaction and heat insulation completion, water is added for hydrolysis reaction; still standing is performed to separate out lower layer water; alkali is added for regulating the pH to 8 to 9; still standing is performed to separate out the lower layer alkali liquid; an organic layer is washed to the neutral state by water; organic solvents are removed through concentration evaporation; next, ethyl alcohol, glacial acetic acid and 80-percent hydrazine hydrate are sequentially added; after hydrazine reaction and heat insulation completion, temperature reduction centrifugation is performed; drying is performed to obtain the 6-chloro-3-amino-3,4-dihydro-4-hydroxyl-4-phenyl quinazoline. The method provided by the invention has the advantages that a low-toxicity solvent is used for replacing high-toxicity dichloroethane; two-step reaction of the formamidine reaction and the hydrazine reaction are completed by a one-pot method; the method has the advantages that the production cost is low; the work procedure steps are few; the operation is simple and convenient; the method is suitable for industrial scaled production.
Methods for the production of 4H-s-triazolo[4,3-a][1,4]benzodiazepine 5N-oxides
-
, (2008/06/13)
The title compounds are prepared by reacting a 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazoline with a reactive derivative of a halogenoacetic acid, reacting the resultant halogenoacetyl derivative with a weak acid, reacting the resultant 2-(3-halomethyl-s-triazol-4-yl)benzophenone with hydroxylamine and subjecting the resultant 2-(3-hydroxyamino-methyl-s-triazol-4-yl)benzophenone to dehydration to effect ring closure.
Heterocycles. VII. Novel and facile syntheses of s triazolo [4,3-a] [1,4] benzodiazepine derivatives
Meguro,Tawada,Kuwada
, p. 1619 - 1621 (2007/10/05)
-
