10352-28-0 Usage
Description
N-(2-Benzoyl-4-chlorophenyl)formamide is an organic compound with the molecular formula C14H10ClNO2. It is a derivative of formamide, featuring a benzoyl group and a chlorophenyl group attached to the nitrogen atom. N-(2-BENZOYL-4-CHLOROPHENYL)FORMAMIDE is characterized by its potential reactivity and utility in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
N-(2-Benzoyl-4-chlorophenyl)formamide is used as a reagent for the synthesis of 2-aminoindole compounds, which are known for their antimalarial properties. These compounds can be further developed and optimized to create effective treatments against malaria, a disease that affects millions of people worldwide.
In the synthesis process, N-(2-Benzoyl-4-chlorophenyl)formamide serves as a key intermediate, providing a platform for the formation of the desired 2-aminoindole structures. Its unique chemical properties, such as the presence of the benzoyl and chlorophenyl groups, enable selective reactions and facilitate the formation of the target compounds with desired biological activities.
The development of new antimalarial agents is crucial due to the increasing resistance of Plasmodium parasites to existing drugs. N-(2-Benzoyl-4-chlorophenyl)formamide, as a versatile reagent, contributes to the ongoing efforts in discovering novel and effective treatments for malaria.
Check Digit Verification of cas no
The CAS Registry Mumber 10352-28-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,3,5 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10352-28:
(7*1)+(6*0)+(5*3)+(4*5)+(3*2)+(2*2)+(1*8)=60
60 % 10 = 0
So 10352-28-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H10ClNO2/c15-11-6-7-13(16-9-17)12(8-11)14(18)10-4-2-1-3-5-10/h1-9H,(H,16,17)
10352-28-0Relevant articles and documents
Mild Access to N-Formylation of Primary Amines using Ethers as C1 Synthons under Metal-Free Conditions
Mutra, Mohana Reddy,Dhandabani, Ganesh Kumar,Wang, Jeh-Jeng
supporting information, p. 3960 - 3968 (2018/09/10)
A new synthetic protocol has been developed for the synthesis of N-formamide derivatives using ethers as a C1 synthon under metal-free reaction conditions. The reaction is proposed to proceed through C?H functionalization, C?O cleavage, and C?N bond formation. This protocol is applicable to a variety of primary amines resulting in N-formamides in moderate to good yields. 1,4-dioxane was chosen as best C1 synthon after screening with various ethers. Mechanistic studies disclosed that the reaction proceeds through a radical pathway. While using α-amino ketones a α-alkylation product was formed rather than formylation. By replacing dioxane with Tetramethylethylenediamine (TMEDA) under standard conditions also gave the N-formamide derivatives in moderate yields. (Figure presented.).
2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA
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Page/Page column 75-76, (2011/05/11)
The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)- The values and preferred values of the variables in Structural Formula I are defined herein.
Synthesis of 2,4-disubstituted quinolines by reactions of o-isocyano-β-methoxystyrene derivatives with organolithiums
Kobayashi, Kazuhiro,Yoneda, Keiichi,Mano, Masaaki,Morikawa, Osamu,Konishi, Hisatoshi
, p. 76 - 77 (2007/10/03)
Alkyl(or aryl)lithiums reacted efficiently with o-isocyano-β-methoxystyrene derivatives, prepared in three steps from o-aminophenyl ketones, to afford the corresponding 2,4-disubstituted quinolines in satisfactory yields.