60628-55-9

Basic information

• Product Name: 2H-1,4-Benzodiazepin-2-one, 7-chloro-3-fluoro-1,3-dihydro-1-methyl-5-phenyl-
• CAS NO: 60628-55-9
• Molecular Formula: C16H12ClFN2O
• Molecular Weight: 302.735
• Mol File: 60628-55-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2H-1,4-Benzodiazepin-2-one, 7-chloro-3-fluoro-1,3-dihydro-1-methyl-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzodiazepin-2-one, 7-chloro-3-fluoro-1,3-dihydro-1-methyl-5-phenyl-(60628-55-9)
• EPA Substance Registry System: 2H-1,4-Benzodiazepin-2-one, 7-chloro-3-fluoro-1,3-dihydro-1-methyl-5-phenyl-(60628-55-9)

Safety Data

• Hazardous Substances Data: 60628-55-9(Hazardous Substances Data)

Upstream product

• 60628-57-1 3-fluoro-5-phenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one 
• 74-88-4 methyl iodide 
• 52395-00-3 N-methyl-N-(2-benzoyl-4-chlorophenyl)formamide 
• 10352-28-0 N-(2-benzoyl-4-chlorophenyl)formamide 
• 60628-73-1 7-chloro-3-fluoro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one N⁴-oxide 
• 359-32-0 chlorofluoroacetyl chloride 
• 5606-40-6 (2-methylamino-5-chlorophenyl)-phenyl-methane-imine 
• 7719-12-2 phosphorus trichloride 
• 253-82-7 quinazoline 
• 70395-32-3 6-chloro-2-chlorofluoromethyl-1,2-dihydro-2-hydroxy-1-methyl-4-phenylquinazoline 
• 2888-64-4 diazepam 4-oxide 
• 963-39-3 demoxepam 
• 604-75-1 oxazepam 
• 846-50-4 temazepam 

Relevant articles and documents

ELECTROPHILIC AND NUCLEOPHILIC APROACHES TO THE SYNTHESIS OF 3-FLUORODIAZEPAM

Electrophilic fluorination of diazepam with elemental fluorine or gas phase acetyl hypofluorite gave 3-fluorodiazepam in 20-60percent yields.Nucleophilic displacement of chlorine in 3-chlorodiazepam by fluoride ion also gave 3-fluorodiazepam in modest yields (maximum: 21percent).Both of these methods were used for the synthesis of 18F-labelled 3-fluorodiazepam.

3-Fluorobenzodiazepines and compositions and uses thereof

3-Fluorobenzodiazepines, such as 3-fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one, useful as tranquilizers, muscle relaxants, and sedatives.

Benzophenone anti-oximes, diazepin-N-oxides, and their use as pharmaceutical agents and as intermediates for pharmaceutical agents

N-Fluorohaloacetyl-N-methylaminobenzophenone anti-oxime, the corresponding diazepin-N-oxides, their use as tranquilizers, muscle relaxants and sedatives, and their use as intermediates in the preparation of 3-fluorobenzodiazepines, which are also useful as tranquilizers, muscle relaxants and sedatives.