276872-89-0 Usage
Description
N-BOC-3-METHYLENE-PIPERIDINE, also known as 1-Boc-3-methylenepiperidine, is an organic compound that serves as a crucial reagent in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a piperidine ring with a methylene group at the 3-position and a tert-butoxycarbonyl (BOC) protecting group at the nitrogen atom. This structure makes it a versatile building block in the development of novel drugs and bioactive molecules.
Uses
Used in Pharmaceutical Industry:
N-BOC-3-METHYLENE-PIPERIDINE is used as a reagent for the preparation of analogs of spirocyclic quinuclidinyl-Δ2-isoxazolines. These analogs are potent and selective α7 nicotinic agonists, which have potential applications in the treatment of various neurological and cognitive disorders, such as Alzheimer's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD). The compound's unique structure allows for the development of new drugs with improved efficacy, safety, and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 276872-89-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,6,8,7 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 276872-89:
(8*2)+(7*7)+(6*6)+(5*8)+(4*7)+(3*2)+(2*8)+(1*9)=200
200 % 10 = 0
So 276872-89-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H19NO2/c1-9-6-5-7-12(8-9)10(13)14-11(2,3)4/h1,5-8H2,2-4H3
276872-89-0Relevant articles and documents
Intramolecular radical rearrangement reactions of 2-methyleneaziridines: Application to the synthesis of substituted piperidines, decahydroquinolines, and octahydroindolizines
Prevost, Natacha,Shipman, Michael
, p. 2383 - 2385 (2001)
(matrix presented) Intramolecular 5-exo cyclization of 3-(2-methyleneaziridin-1-yl)propyl radicals leads to the generation of a highly strained, bicyclic aziridinylcarbinyl radical that undergoes C-N bond fission to the ring-expanded aminyl radical. This
AMIDE DERIVATIVES COMPRISING HETEROCYCLOALKYL RING
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Paragraph 0239-0241, (2020/05/20)
PROBLEM TO BE SOLVED: To provide compounds or pharmacologically acceptable salts thereof that have excellent EP300 and/or CREBBP histone acetyltransferase inhibitory activity. SOLUTION: The invention provides compounds represented by the formula (1) in the figure or pharmacologically acceptable salts thereof. (In the formula (1), ring Q1, ring Q2, ring Q3, X and L are as defined in the specification.) SELECTED DRAWING: None COPYRIGHT: (C)2020,JPO&INPIT
SPIROCYCLIC MOLECULES AS PROTEIN KINASE INHIBITORS
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Paragraph 00253-00255, (2013/03/26)
The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fiuorophenyl) ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers