27866-27-9 Usage
Description
(E)-6,7-Dihydro-1H-indol-4(5H)-one oxime, commonly known as dimethindene, is a chemical compound with a wide range of applications in the pharmaceutical industry. It is characterized by its antihistaminic and smooth muscle-relaxant properties, making it a versatile agent for treating various conditions.
Uses
Used in Pharmaceutical Industry:
(E)-6,7-Dihydro-1H-indol-4(5H)-one oxime is used as an antipruritic and antivertiginous agent for the treatment of allergic reactions, itching, and motion sickness. It acts by blocking the action of histamine at H1-receptor sites, providing rapid onset of action and long-lasting effects.
Used in Over-the-Counter Products:
Dimethindene is also utilized in over-the-counter products for the relief of symptoms associated with allergic rhinitis, urticaria, and eczema, offering a convenient and accessible solution for consumers.
Used in Neuroprotective Applications:
(E)-6,7-Dihydro-1H-indol-4(5H)-one oxime has been investigated for its potential as a neuroprotective agent, showing promise for the treatment of neurodegenerative diseases. Its ability to protect neurons and reduce inflammation makes it a promising candidate for further research and development in this area.
Used in Anti-Inflammatory Applications:
(E)-6,7-DIHYDRO-1H-INDOL-4(5H)-ONE OXIME has also demonstrated potential as an anti-inflammatory agent, making it a candidate for the treatment of various inflammatory conditions. Its effectiveness in reducing inflammation and alleviating symptoms could lead to new therapeutic options for patients suffering from such conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 27866-27-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,8,6 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 27866-27:
(7*2)+(6*7)+(5*8)+(4*6)+(3*6)+(2*2)+(1*7)=149
149 % 10 = 9
So 27866-27-9 is a valid CAS Registry Number.
27866-27-9Relevant articles and documents
Regioselective synthesis of several heterocyclic fused azepines using diisobutylaluminum hydride
Cho, Hidetsura,Murakami, Kengo,Nakanishi, Hiroyuki,Isoshima, Hirotaka,Hayakawa, Kazuhide,Uchida, Itsuo
, p. 919 - 927 (2007/10/03)
5,6,7,8-Tetrahydrothieno[3,2-b]azepine,5,6,7,8-tetrahydro-1H-furo[3,2-b] azepine, and 1,4,5,6,7,8-hexahydropyrrolo[3,2-b]azepine were synthesized by the ring expansion reaction of heterocyclic fused cyclohexanone oximes with diisobutylaluminum hydride (DIBAH). The mechanism of the reaction was different from that of Beckmann rearrangement.
