13754-86-4 Usage
Description
1,5,6,7-Tetrahydro-4H-indol-4-one is an organic compound that serves as a versatile building block in the synthesis of more complex pharmaceutical compounds. It is characterized by its unique chemical structure, which allows for various modifications and applications in the field of drug development.
Uses
1. Used in Pharmaceutical Synthesis:
1,5,6,7-Tetrahydro-4H-indol-4-one is used as a reactant in the synthesis of Psammopemmin A, an antitumor agent. Its unique structure makes it a valuable component in the development of new cancer treatments.
2. Used in Organic Chemistry:
1,5,6,7-Tetrahydro-4H-indol-4-one is used as a reactant in the synthesis of 1,3,4,5-tetrahydrobenzindole β-ketoesters and tricyclic tetrahydrobenzindoles via C-H insertion reactions. These compounds have potential applications in various chemical and pharmaceutical processes.
3. Used in Enzyme Inhibition:
1,5,6,7-Tetrahydro-4H-indol-4-one is used as a reactant in the preparation of tricyclic indole and dihydroindole derivatives, which act as inhibitors of guanylate cyclase. These inhibitors can be used in the development of drugs targeting specific enzyme pathways.
4. Used in Condensed Pyrroloindole Synthesis:
1,5,6,7-Tetrahydro-4H-indol-4-one is used as a reactant in the preparation of condensed pyrroloindoles via Pd-catalyzed intramolecular C-H bond functionalization of (halobenzyl)pyrroles. These condensed pyrroloindoles have potential applications in the development of novel pharmaceutical compounds.
5. Used in Asymmetric Synthesis:
1,5,6,7-Tetrahydro-4H-indol-4-one is used as a reactant in the enantioselective preparation of arylalkenyl indoles via asymmetric C-H insertion of rhodium carbenoids. This process allows for the creation of chiral molecules with specific configurations, which can be crucial in the development of effective drugs with minimal side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 13754-86-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,5 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13754-86:
(7*1)+(6*3)+(5*7)+(4*5)+(3*4)+(2*8)+(1*6)=114
114 % 10 = 4
So 13754-86-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO/c10-8-3-1-2-7-6(8)4-5-9-7/h4-5,9H,1-3H2
13754-86-4Relevant articles and documents
ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR
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Paragraph 0208; 0211; 0212, (2017/06/12)
The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.
Formation of N-substituted 4- and 7-oxo-4,5,6,7-tetrahydroindoles revisited: A mechanistic interpretation and conversion into 4- and 7-oxoindoles
Montalban, Antonio Garrido,Baum, Sven M.,Cowell, Justin,McKillop, Alexander
experimental part, p. 4276 - 4279 (2012/09/25)
An efficient method for the preparation of 4-oxo-4,5,6,7-tetrahydroindoles was successfully applied to the synthesis of N-substituted 7-oxo-4,5,6,7- tetrahydroindoles for the first time. Both isomers where converted into their corresponding 4- and 7-oxoindoles in good yields utilizing a novel aromatization protocol. Based on the impurity profile obtained, however, different mechanisms for the formation of the 4- and 7-oxo-4,5,6,7-tetrahydroindole derivatives are discussed. In addition, the reaction sequences appear to be stereospecific allowing for the direct introduction of a chiral center α to the nitrogen and preparation of enantiomerically enriched products.
Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase
Spyridonidou, Katerina,Fousteris, Manolis,Antonia, Marazioti,Chatzianastasiou, Athanasia,Papapetropoulos, Andreas,Nikolaropoulos, Sotiris
supporting information; experimental part, p. 4810 - 4813 (2010/04/26)
The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.
