877170-76-8 Usage
General Description
The chemical 4,5,6,7-Tetrahydro-4-oxo-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester, also known as Tacrolimus, is a potent immunosuppressive drug used to prevent organ rejection in transplant patients. It is a macrolide lactone with a cyclic structure and is derived from the fungus Streptomyces tsukubaensis. Tacrolimus works by inhibiting the activation of T-lymphocytes, thereby reducing the immune response and preventing rejection of the transplanted organ. It is commonly administered orally or topically and is known for its high efficacy and relatively low incidence of adverse effects compared to other immunosuppressive drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 877170-76-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,7,1,7 and 0 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 877170-76:
(8*8)+(7*7)+(6*7)+(5*1)+(4*7)+(3*0)+(2*7)+(1*6)=208
208 % 10 = 8
So 877170-76-8 is a valid CAS Registry Number.
877170-76-8Relevant articles and documents
ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR
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, (2017/06/12)
The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.
4-Substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles and methods for making same
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Page/Page column 23, (2010/11/25)
Disclosed are 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles. Also disclosed are methods for making 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazo
