283173-83-1

Basic information

• Product Name: 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.
• Synonyms: 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.;1-[(4-Bromo-2-fluorophenyl)methyl]pyrrolidine;4-Bromo-2-fluorophenyl-1-(pyrrolidinomethyl)benzene;Pyrrolidine,1-[(4-bromo-2-fluorophenyl)methyl]-
• CAS NO: 283173-83-1
• Molecular Formula: C11H13BrFN
• Molecular Weight: 258.14
• Product Categories: alkyl bromide|alkyl Fluorine
• Mol File: 283173-83-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 281.627°C at 760 mmHg
• Flash Point: 124.124°C
• Appearance: /
• Density: 1.446g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.(283173-83-1)
• EPA Substance Registry System: 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.(283173-83-1)

Safety Data

• Hazardous Substances Data: 283173-83-1(Hazardous Substances Data)

Usage

Description

1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN. is a chemical compound characterized by a pyrrolidine ring and a benzyl group, featuring bromine and fluorine substituents. 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN. is known for its high purity, which makes it a reliable and consistent component in various chemical reactions.

Uses

Used in Pharmaceutical Industry:
1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN. is used as a building block for the synthesis of various pharmaceuticals. Its high purity and unique structure contribute to the development of new drugs and biologically active compounds, making it a valuable asset in the pharmaceutical industry.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN. is utilized as a key intermediate in the production of agrochemicals. Its role in creating effective and reliable products highlights its importance in this field.
Used in Fine Chemicals Industry:
1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN. is also employed in the synthesis of fine chemicals, where its high purity and unique chemical structure are essential for creating specialized compounds with specific applications.
Used in Research and Development:
Due to its high purity and consistency, 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN. is a sought-after compound for research and development in both the pharmaceutical and agrochemical industries. It serves as a crucial component in the creation of innovative and effective products.

InChI:InChI=1/C11H13BrFN/c12-10-4-3-9(11(13)7-10)8-14-5-1-2-6-14/h3-4,7H,1-2,5-6,8H2

Upstream product

• 123-75-1 pyrrolidine 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Relevant articles and documents

Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode

Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an embedded Ames-positive heteroaromatic amine by reversing a sulfonamide followed by locating an interaction with Trp760 led to a highly selective compound 9 . Further optimization to avoid glutathione trapping, to enhance potency and selectivity, and to optimize an oral pharmacokinetic profile led to the discovery of compound 31 (GSK215) that had a low predicted daily dose (45 mg, b.i.d) and a rat toxicity profile suitable for further development.

Discovery of two clinical histamine H3 receptor antagonists: Trans - N -ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl] cyclobutanecarboxamide (PF-03654746) and trans -3-fluoro-3-[3-fluoro-4- (pyrrolidin-1-ylmethyl)phenyl]- N -(2-methy

The discovery of two histamine H3 antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success i