284030-62-2

Basic information

• Product Name: 1H-Benzimidazole-5-carboxylic acid, 7-fluoro-6-[(4-iodo-2-methylphenyl)amino]-, methyl ester
• CAS NO: 284030-62-2
• Molecular Formula: C16H13FIN3O2
• Molecular Weight: 425.201
• Mol File: 284030-62-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole-5-carboxylic acid, 7-fluoro-6-[(4-iodo-2-methylphenyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-5-carboxylic acid, 7-fluoro-6-[(4-iodo-2-methylphenyl)amino]-, methyl ester(284030-62-2)
• EPA Substance Registry System: 1H-Benzimidazole-5-carboxylic acid, 7-fluoro-6-[(4-iodo-2-methylphenyl)amino]-, methyl ester(284030-62-2)

Safety Data

• Hazardous Substances Data: 284030-62-2(Hazardous Substances Data)

Upstream product

• 284030-61-1 methyl 7-fluoro-6-(2-methyl-phenylamino)-1H-benzoimidazole-5-carboxylate 
• 114971-52-7 N,N,N-trimethylbenzenemethanaminium dichloroiodate 
• 284030-61-1 7-Fluoro-6-o-tolylamino-3H-benzoimidazole-5-carboxylic acid methyl ester 

Downstream Products

• 284486-91-5 PD 205293 
• 606093-56-5 7-fluoro-6-(4-iodo-2-methyl-phenylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid methyl ester 

Relevant articles and documents

METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS

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N3 alkylated benzimidazole derivatives as MEK inhibitors

Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.

Benzoheterocycles and their uses as MEK inhibitors

The invention provides compounds having formula (I), wherein W is OH, or derivatives of the carboxylic acid, and Q is a heterocyclo-condensed ortho-phenylene residue. These compounds are useful as MEK inhibitors, particularly in the treatment of proliferative diseases such as cancer.