28687-81-2

Basic information

• Product Name: 5(4H)-Oxazolone, 2,4-diphenyl-
• Synonyms: 5(4H)-Oxazolone, 2,4-diphenyl-;2,4-Diphenyl-2-oxazolin-5-one;Azlactone;2,4-diphenyl-1,3-oxazol-5(4h)-one;2,4-diphenyl-4H-1,3-oxazol-5-one
• CAS NO: 28687-81-2
• Molecular Formula: C₁₅H₁₁NO₂
• Molecular Weight: 237.25
• Mol File: 28687-81-2.mol
• Article Data: 24

Chemical Properties

• Melting Point: 100 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 368.5°Cat760mmHg
• Flash Point: 169.2°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Refractive Index: 1.621
• PKA: 1.78±0.40(Predicted)
• CAS DataBase Reference: 5(4H)-Oxazolone, 2,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 2,4-diphenyl-(28687-81-2)
• EPA Substance Registry System: 5(4H)-Oxazolone, 2,4-diphenyl-(28687-81-2)

Safety Data

• Hazardous Substances Data: 28687-81-2(Hazardous Substances Data)

Usage

General Description

5(4H)-Oxazolone, 2,4-diphenyl- is a chemical compound with the molecular formula C15H11NO2. It is a substituted oxazolone, which is a five-membered heterocyclic compound containing oxygen, nitrogen, and carbon atoms. 5(4H)-Oxazolone, 2,4-diphenyl- is commonly used in the synthesis of various pharmaceutical and agrochemical products. Its structure and reactivity make it suitable for use as a building block in organic synthesis, particularly for the preparation of complex molecules with potential biological activities. Additionally, 5(4H)-Oxazolone, 2,4-diphenyl- has been studied for its potential as a material for various applications, such as optoelectronic devices and organic semiconductors. Overall, this compound has a wide range of potential uses in the fields of chemistry, pharmaceuticals, and materials science.

InChI:InChI=1/C15H11NO2/c17-15-13(11-7-3-1-4-8-11)16-14(18-15)12-9-5-2-6-10-12/h1-10,13H

Upstream product

• 29670-63-1 N-benzoyl-2-phenylglycine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 111796-04-4 4-(2,4-diphenyl-oxazol-5-yl)-pyridine 
• 111796-60-2 2,4-diphenyl-5-(pyridin-3-yl)oxazole 
• 102662-37-3 benzoic acid-(2,4-diphenyl-oxazol-5-yl ester) 
• 19035-30-4 1,4-diphenyl-7-aza-bicyclo[2.2.1]heptane-2exo,3exo,5exo,6exo-tetracarboxylic acid 2,3;5,6-dianhydride 
• 61728-53-8 2,4,2',4'-tetraphenyl-2H,4'H-[2,4']bioxazolyl-5,5'-dione 
• 91527-87-6 2,4-Diphenyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-4H-oxazol-5-one 
• 91527-88-7 2,4-Diphenyl-4-[3-(tetrahydro-pyran-2-yloxy)-propyl]-4H-oxazol-5-one 
• 98767-88-5 N-(2-Furan-2-yl-1-methyl-4-oxo-3-phenyl-azetidin-3-yl)-benzamide 
• 98767-85-2 N-(1-Methyl-2-oxo-3-phenyl-4-thiophen-2-yl-azetidin-3-yl)-benzamide 
• 62045-88-9 methyl (R)-2-benzoylamino-2-phenylacetate 
• 81912-50-7 (S)-benzoylamino-phenyl-acetic acid methyl ester 
• 95885-55-5 4-isopropyl-2,4-diphenyl-4H-oxazol-5-one 
• 95885-60-2 2,4-Diphenyl-4-(2,4-dinitrophenyl)-2-oxazolidin-5-one 
• 98767-84-1 N-(1-Ethyl-2-oxo-3-phenyl-4-thiophen-2-yl-azetidin-3-yl)-benzamide 

Relevant articles and documents

Enantioselective iridium catalyzed α-alkylation of azlactones by a tandem asymmetric allylic alkylation/aza-Cope rearrangement

The development of an iridium catalyzed enantioselective α-alkylation of azlactones has been described. The reaction provides rapid access to a wide range of enantio-enriched quaternary carbon center allylated 2,4-diaryloxazol-5(2H)-ones in excellent yiel

Alkynyliodonium salt mediated alkynylation of azlactones: Fast access to Cα-tetrasubstituted α-amino acid derivatives

An efficient electrophilic alkynylation of azlactones (oxazol-5(4H)-ones) is developed using alkynyl(phenyl)iodonium salts as the electrophilic alkyne source. After remarkably short reaction times, the desired alkyne functionalized azlactones are obtained in 60-97% yield and can be transformed easily into a variety of quaternary α-amino acid derivatives.

Synthesis of di- and tri-substituted imidazole-4-carboxylates via PBu3-mediated [3+2] cycloaddition

Some new di- and trisubstituted imidazole-4-carboxylates were prepared from amidoacetic acids 3 in the present report. The key step to establish such imidazole- 4-carboxylates stemmed from the PBu3-mediated [3+2] cycloaddition between in situ-generated Δ2-oxazolinone 4 and ethyl cyanoformate6. Our results indicated that trisubstituted imidazoles 7-20 were afforded in better yields than those of disubstituted imidazoles 21-27. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.