81912-50-7

Basic information

• Product Name: (S)-benzoylamino-phenyl-acetic acid methyl ester
• Synonyms: (S)-benzoylamino-phenyl-acetic acid methyl ester
• CAS NO: 81912-50-7
• Molecular Weight: 269.3
• Mol File: 81912-50-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (S)-benzoylamino-phenyl-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzoylamino-phenyl-acetic acid methyl ester(81912-50-7)
• EPA Substance Registry System: (S)-benzoylamino-phenyl-acetic acid methyl ester(81912-50-7)

Safety Data

• Hazardous Substances Data: 81912-50-7(Hazardous Substances Data)

Upstream product

• 7352-07-0 N-benzoyl-α-phenylglycine 
• 74-88-4 methyl iodide 
• 65-85-0 benzoic acid 
• 22979-35-7 Methyl phenyldiazoacetate 
• 55-21-0 benzamide 
• 1176540-37-6 (1S,1'S)-1,1'-(1-benzoyl-1H-1,2,4-triazole-3,5-diyl)-bis(ethane-1,1-diyl) dibenzoate 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 2935-35-5 (S)-2-phenylglycine 
• 952524-02-6 (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole 
• 24461-61-8 phenylglycine methyl ester 
• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 
• 98-88-4 benzoyl chloride 
• 67-56-1 methanol 
• 28687-81-2 2,4-diphenyl-4H-oxazol-5-one 

Downstream Products

• 1221966-74-0 (S)-N-(2-(methoxy(methyl)amino)-2-oxo-1-phenylethyl)benzamide 
• 74213-58-4 N-[(1R)-2-hydroxy-1-phenylethyl]benzamide 
• 163010-72-8 N-benzoyl-(S)-phenylglycinal 
• 116126-04-6 (-)-N-((S)-2-hydroxy-1-phenylethyl)benzamide 

Relevant articles and documents

Weak coordinated nitrogen functionality enabled regioselective C-H alkynylationviaPd(ii)/mono-N-protected amino acid catalysis

The exploration of weak coordinated amine derivative enabled regioselective C-H functionalization remains challenging due to the elusive achievement of reactivity and selectivity simultaneously. Herein, regioselective C-H alkynylation of various readily transformable nitrogen functionalities was developed with great efficiency, with the assistance of the mono-N-protected amino acid (MPAA) ligandviaPd(ii) catalysis proceedingvia5, 6 and 7-membered palladacycle intermediates.

A novel method for synthesizing N-alkoxycarbonyl aryl α-imino esters and their applications in enantioselective transformations

A new strategy for the synthesis of N-alkoxycarbonyl aryl α-imino esters in the presence of dirhodium tetraacetate [Rh2(OAc) 4] is reported to produce the desired compounds in high yield (up to 96%) under mild reaction conditions. The application of the synthetic method is demonstrated in enantioselective reduction and Friedel-Crafts reaction of indoles to afford the corresponding chiral arylglycines and indole derivatives, respectively, in high yield and excellent ee. Copyright

Tricyclononene carboxamide derivatives as novel anti-HIV-1 agents

By modifying the chemical structure of anti-orthopoxvirus compound ST-246, we designed and synthesized a series of tricyclononene carboxamide derivatives and tested their anti-HIV-1 activity and cytotoxicity. We found that benzoimidazol-containing compound 7g was highly effective in inhibiting HIV-1 R5 infection with an IC50 value of 0.41 μM and a selectivity index of 292, but it exhibited no significant inhibitory activity on HIV-1 reverse transcriptase, integrase and protease. CoMFA was used to analyze structure-activity relationships with good predictive power (r2 = 0.921; q2 = 0.582). Moreover, the CoMFA model showed that the length of the molecule, the amide, and the amine moieties all played crucial roles in anti-HIV activity. These results suggest that 7g may serve as a lead for the development of novel anti-HIV-1 therapies. A series of tricyclononene carboxamide derivatives based on anti-orthopoxvirus compound ST-246 were synthesized and characterized as novel anti-HIV-1 agents.