287408-24-6

Basic information

• Product Name: (S)-4-[4-(7-Hydroxy-hept-2-ynyloxy)-benzenesulfonyl]-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester
• CAS NO: 287408-24-6
• Molecular Weight: 455.596
• Mol File: 287408-24-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-[4-(7-Hydroxy-hept-2-ynyloxy)-benzenesulfonyl]-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-[4-(7-Hydroxy-hept-2-ynyloxy)-benzenesulfonyl]-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester(287408-24-6)
• EPA Substance Registry System: (S)-4-[4-(7-Hydroxy-hept-2-ynyloxy)-benzenesulfonyl]-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester(287408-24-6)

Safety Data

• Hazardous Substances Data: 287408-24-6(Hazardous Substances Data)

Upstream product

• 31608-23-8 7-(tetrahydro-2H-pyran-2-yloxy)hept-2-yn-1-ol 
• 4025-67-6 4-hydroxybenzene-1-sulfonyl chloride 
• 1720-37-2 2-(hex-5-yn-1-yloxy)tetrahydro-2H-pyran 
• 287408-09-7 (S)-4-(4-Hydroxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester 
• 287408-23-5 (S)-2,2-Dimethyl-4-{4-[7-(tetrahydro-pyran-2-yloxy)-hept-2-ynyloxy]-benzenesulfonyl}-thiomorpholine-3-carboxylic acid methyl ester 
• 192329-86-5 methyl (3S)-2,2-dimethylthiomorpholine-3-carboxylate 

Downstream Products

• 287408-26-8 4-[4-(7-tert-butoxycarbonylamino-hept-2-ynyloxy)-benzenesulfonyl]-2,2-dimethyl-thiomorpholine-3-carboxylic acid 
• 287408-25-7 4-[4-(7-tert-butoxycarbonylamino-hept-2-ynyloxy)-benzenesulfonyl]-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester 

Relevant articles and documents

Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates

A series of thiomorpholine sulfonamide hydroxamate TACE inhibitors, all bearing propargylic ether P1′ groups, was explored. In particular, compound 5h has excellent in vitro potency against isolated TACE enzyme and in cells, oral activity in a model of TN