287408-25-7Relevant articles and documents
Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates
Levin,Chen,Laakso,Du,Schmid,Xu,Cummons,Xu,Jin,Barone,Skotnicki
, p. 1605 - 1609 (2007/10/03)
A series of thiomorpholine sulfonamide hydroxamate TACE inhibitors, all bearing propargylic ether P1′ groups, was explored. In particular, compound 5h has excellent in vitro potency against isolated TACE enzyme and in cells, oral activity in a model of TN