2879-14-3 Usage
Description
8-Phenyl-1H-purine-2,6(3H,7H)-dione, also known as 8-Phenylxanthine, is an organic compound belonging to the purine family. It is characterized by its unique molecular structure, which features a phenyl group attached to the 8th position of the purine ring. 8-Phenyl-1H-purine-2,6(3H,7H)-dione is known for its potential applications in various fields due to its chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
8-Phenyl-1H-purine-2,6(3H,7H)-dione is used as a reactant for the preparation of xanthine derivatives, which are known to act as adenosine A1 receptor antagonists. These antagonists have potential applications in the treatment of various conditions, such as neurological disorders, cardiovascular diseases, and certain types of cancer. 8-Phenyl-1H-purine-2,6(3H,7H)-dione's ability to form xanthine derivatives with antagonistic properties makes it a valuable component in the development of new pharmaceuticals.
Used in Chemical Research:
In addition to its pharmaceutical applications, 8-Phenyl-1H-purine-2,6(3H,7H)-dione can also be utilized in chemical research for the synthesis of various purine-based compounds. Its unique structure allows for further modification and functionalization, enabling the creation of novel molecules with potential applications in different industries, such as materials science, agrochemistry, and more.
Check Digit Verification of cas no
The CAS Registry Mumber 2879-14-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,7 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2879-14:
(6*2)+(5*8)+(4*7)+(3*9)+(2*1)+(1*4)=113
113 % 10 = 3
So 2879-14-3 is a valid CAS Registry Number.
2879-14-3Relevant articles and documents
Synthesis and biological properties of C-2, C-8, N-9 substituted 6-(3-chloroanilino)-purine derivatives as cyclin-dependent kinase inhibitors. Part II
Oh, Chang-Hyun,Kim, Hee-Kwon,Lee, Su-Chul,Oh, Changsok,Yang, Boem-Seok,Rhee, Hak June,Cho, Jung-Hyuck
, p. 345 - 350 (2007/10/03)
In this study, C-2, C-8, N-9 substituted 6-(3-chloroanilino)purine derivatives were synthesized and their inhibitory effects on cyclin-dependent kinases (CDK2, 4) as well as their cytotoxicities were evaluated. The effects of substituents at the C-2, C-8, and N-9 positions of the substituted purine were investigated. Among the compounds tested, [6-(3-chloroanilino)-2-(2-hydroxymethyl-4-hydroxypyrrolidyl)- 9-isopropylpurine] (4h) was the most active inhibitor of CDK2 with IC50 of 0.3μM i.e. a two-fold increased inhibitory activity as compared to roscovitine. Results from structure-activity relationship studies should allow the design of more potent and selective CDK2 inhibitors, which may provide an effective therapy for cancer or other CDK-dependent diseases.
OXIDATIVE CYCLOCONDENSATION OF TRIALKYLAMMONIUM SALTS WITH DIAMINES
Popov, I. I.,Pozharskii, A. F.
, p. 1030 (2007/10/02)
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