412918-55-9

Basic information

• Product Name: 2,6-dichloro-8-phenyl-9H-purine
• CAS NO: 412918-55-9
• Molecular Weight: 265.101
• Mol File: 412918-55-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-dichloro-8-phenyl-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dichloro-8-phenyl-9H-purine(412918-55-9)
• EPA Substance Registry System: 2,6-dichloro-8-phenyl-9H-purine(412918-55-9)

Safety Data

• Hazardous Substances Data: 412918-55-9(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 2879-14-3 8-phenyl-9H-purine-2,6-diol 

Relevant articles and documents

Synthesis and biological properties of C-2, C-8, N-9 substituted 6-(3-chloroanilino)-purine derivatives as cyclin-dependent kinase inhibitors. Part II

In this study, C-2, C-8, N-9 substituted 6-(3-chloroanilino)purine derivatives were synthesized and their inhibitory effects on cyclin-dependent kinases (CDK2, 4) as well as their cytotoxicities were evaluated. The effects of substituents at the C-2, C-8, and N-9 positions of the substituted purine were investigated. Among the compounds tested, [6-(3-chloroanilino)-2-(2-hydroxymethyl-4-hydroxypyrrolidyl)- 9-isopropylpurine] (4h) was the most active inhibitor of CDK2 with IC50 of 0.3μM i.e. a two-fold increased inhibitory activity as compared to roscovitine. Results from structure-activity relationship studies should allow the design of more potent and selective CDK2 inhibitors, which may provide an effective therapy for cancer or other CDK-dependent diseases.