28819-05-8Relevant articles and documents
Sparsomycin analogs. II. Synthesis and biological activities of 5-carboxy-6-methyluracil derivatives
Kanamoto,Nagai,Hase,et al.
, p. 135 - 143 (1983)
In order to study the structure-activity relationship of sparsomycin, an antitumor antibiotic, 26 sparsomycin-related compounds were synthesized and their antibacterial activities and lytic actions on Ehrlich ascites carcinoma cells were tested.
Preparation method of carboxylic ester compound
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Paragraph 0044-0045, (2021/03/30)
The invention relates to a preparation method of a carboxylic ester compound, which comprises the following steps: reacting carboxylic acid with methanol in air under the catalysis of nitrite to obtain an ester compound, the preparation method disclosed by the invention has the advantages of rich raw material sources, cheap and easily available catalyst, mild reaction conditions, simplicity and convenience in operation and the like, a series of fatty carboxylic acids can be modified with high yield, and particularly, the traditional esterification method is generally not suitable for esterification of drug molecules. By utilizing the method, a series of known drug molecules can be modified, so that a shortcut is provided for discovering new drug molecules.
A Mild, General, Metal-Free Method for Desulfurization of Thiols and Disulfides Induced by Visible-Light
Qiu, Wenting,Shi, Shuai,Li, Ruining,Lin, Xianfeng,Rao, Liangming,Sun, Zhankui
supporting information, p. 1255 - 1258 (2021/05/05)
A visible-light-induced metal-free desulfurization method for thiols and disulfides has been explored. This radical desulfurization features mild conditions, robustness, and excellent functionality compatibility. It was successfully applied not only to the desulfurization of small molecules, but also to peptides.