6429-44-3

Basic information

• Product Name: (S)-benzyl (1-hydroxypropan-2-yl)carbamate
• CAS NO: 6429-44-3
• Molecular Weight: 209.245
• Mol File: 6429-44-3.mol
• Article Data: 60

Chemical Properties

• CAS DataBase Reference: (S)-benzyl (1-hydroxypropan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzyl (1-hydroxypropan-2-yl)carbamate(6429-44-3)
• EPA Substance Registry System: (S)-benzyl (1-hydroxypropan-2-yl)carbamate(6429-44-3)

Safety Data

• Hazardous Substances Data: 6429-44-3(Hazardous Substances Data)

Usage

Description

(S)-Benzyl (1-hydroxypropan-2-yl)carbamate, a carbamate derivative with a molecular formula C12H17NO3, features a benzyl group and a hydroxypropan-2-yl group attached to the carbamate function. As a chiral molecule, it has a stereocenter at the carbon atom bearing the carbamate group, leading to two enantiomers: the (S)and (R)forms. (S)-benzyl (1-hydroxypropan-2-yl)carbamate is known for its role as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and it also holds potential in organic chemistry for creating various organic compounds.

Uses

Used in Pharmaceutical Synthesis:
(S)-Benzyl (1-hydroxypropan-2-yl)carbamate is used as an intermediate for the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, (S)-benzyl (1-hydroxypropan-2-yl)carbamate is utilized as an intermediate in the production of various agrochemicals, contributing to the development of effective solutions for agricultural needs.
Used in Organic Chemistry:
(S)-Benzyl (1-hydroxypropan-2-yl)carbamate serves as a building block in organic chemistry for the preparation of a wide range of organic compounds. Its versatile structure enables the creation of novel molecules with potential applications in various fields.

Upstream product

• 6168-72-5 2-Amino-1-propanol 
• 501-53-1 benzyl chloroformate 
• 28819-05-8 (S)-2-benzyloxycarbonylamino-propionic acid methyl ester 
• 24850-33-7 allyltributylstanane 
• 111061-31-5 1-phenoxy-1-trimethylsilyloxyethene 
• 99790-15-5 ((S)-2-Imidazol-1-yl-1-methyl-2-oxo-ethyl)-carbamic acid benzyl ester 
• 3401-36-3 (N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester 
• 25172-67-2 Z-Ala-O-COO-isoBu 
• 82353-55-7 benzyl (S)-1-oxopropan-2-ylcarbamate 
• 56-41-7 L-alanin 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 2749-11-3 (S)-Alaninol 
• 65638-93-9 N-Carbobenzoxy-L-alanin-kohlensaeureaethylesteranhydrid 
• 1142-20-7 N-Cbz-Ala 

Downstream Products

• 946088-68-2 benzyl 2-methylaziridine-1-carboxylate 
• 667452-19-9 2-(benzyloxycarbonylamino)propyl methanesulfonate 
• 429669-51-2 [(1S)-2-(t-butyldiphenylsilyloxy)-1-methyl-ethyl]carbamic acid benzyl ester 
• 105499-10-3 (1(S)-methyl-2-oxo-ethyl)-carbamic acid benzyl ester 
• 913625-36-2 2-(S)-2-(benzyloxycarbonyl)amino-N-(3-hydroxypropyl)propylamine 
• 1140948-93-1 (S)-2-benzyloxycarbonylaminopropyl thiolacetate 
• 1140948-95-3 Cbz-Ala-ψ[CH2SO2]-Cl 
• 1169199-21-6 Cbz-Ala-ψ[CH2SO2]-F 
• 1300858-65-4 C₁₁H₁₅NO₅S 
• 866933-34-8 (S)-N-(2-benzyloxycarbonylamino-prop-1-yl)-N-methyl-amine 
• 2460687-71-0 (S)-1-(4'-nitropyrazole)-2-propylbenzyloxyamide 
• 2460687-74-3 1-(4'-amino-5'-carbamoyl-1'-pyrazolyl)-(S)-2-propylbenzyloxyamide 
• 1011466-04-8 2-(S)-2-(benzyloxycarbonyl)amino-N-(tert-butoxycarbonyl)-N-(2-tert-butyldimethylsilyloxyethyl)propylamine 
• 1011466-03-7 2-(S)-2-(benzyloxycarbonyl)amino-N-(tert-butoxycarbonyl)-N-(2-hydroxyethyl)propylamine 

Relevant articles and documents

Novel sulfonamide-based carbamates as selective inhibitors of bche

A series of 14 target benzyl [2-(arylsulfamoyl)-1-substituted-ethyl]carbamates was prepared by multi-step synthesis and characterized. All the final compounds were tested for their abil-ity to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase

Enantioconvergent Cu-Catalyzed Radical C-N Coupling of Racemic Secondary Alkyl Halides to Access α-Chiral Primary Amines

α-Chiral alkyl primary amines are virtually universal synthetic precursors for all other α-chiral N-containing compounds ubiquitous in biological, pharmaceutical, and material sciences. The enantioselective amination of common alkyl halides with ammonia is appealing for potential rapid access to α-chiral primary amines, but has hitherto remained rare due to the multifaceted difficulties in using ammonia and the underdeveloped C(sp3)-N coupling. Here we demonstrate sulfoximines as excellent ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides (>60 examples) by copper catalysis under mild thermal conditions. The reaction efficiently provides highly enantioenrichedN-alkyl sulfoximines (up to 99% yield and >99% ee) featuring secondary benzyl, propargyl, α-carbonyl alkyl, and α-cyano alkyl stereocenters. In addition, we have converted the masked α-chiral primary amines thus obtained to various synthetic building blocks, ligands, and drugs possessing α-chiral N-functionalities, such as carbamate, carboxylamide, secondary and tertiary amine, and oxazoline, with commonly seen α-substitution patterns. These results shine light on the potential of enantioconvergent radical cross-coupling as a general chiral carbon-heteroatom formation strategy.

Chiral pyrazole derivative and synthesis method thereof

The invention belongs to the technical field of organic synthesis, and discloses a chiral pyrazole derivative and a synthesis method thereof. The chiral pyrazole derivative is (1-(4'-amino-5'-carbamoyl-1'-pyrazolyl)-(S)-2-propyl-benzyloxy amide. The synth