288309-07-9

Basic information

• Product Name: Benzonitrile, 5-acetyl-2-fluoro- (9CI)
• Synonyms: Benzonitrile, 5-acetyl-2-fluoro- (9CI);Benzonitrile, 5-acetyl-2-fluoro-;2-Fluoro-5-acetylbenzonitrile
• CAS NO: 288309-07-9
• Molecular Formula: C₉H₆FNO
• Molecular Weight: 163.1484432
• Product Categories: HALIDE;ACETYLGROUP
• Mol File: 288309-07-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 277.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Benzonitrile, 5-acetyl-2-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 5-acetyl-2-fluoro- (9CI)(288309-07-9)
• EPA Substance Registry System: Benzonitrile, 5-acetyl-2-fluoro- (9CI)(288309-07-9)

Safety Data

• Hazardous Substances Data: 288309-07-9(Hazardous Substances Data)

Usage

General Description

Benzonitrile, 5-acetyl-2-fluoro- (9CI) is a chemical compound with molecular formula C9H6FNO. This organic compound belongs to the group of benzonitriles, which are aromatic compounds containing a cyanide group attached to a benzene ring. The 5-acetyl-2-fluoro- denotes the arrangement of fluorine and acetyl functional groups on the benzene ring. The primary use of such compounds is typically in the synthesis of more complex chemical products. Its physical and chemical properties, toxicity, and potential risks to the environment are determined by various factors, such as its structure and reactivity. It is vital to handle this chemical with care due to potential hazards associated with its use and disposal.

Upstream product

• 960244-29-5 2-fluoro-5-(1-hydroxyethyl)benzonitrile 
• 1007-15-4 4-fluoro-3-bromoacetophenone 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 218301-22-5 2-fluoro-5-formylbenzonitrile 
• 1220124-55-9 3-bromo-4-fluoro-N-methoxy-N-methylbenzamide 
• 1007-16-5 3-bromo-4-fluorobenzoic acid 
• 135205-66-2 N?cyanosuccinimide 
• 870777-29-0 (5-acetyl-2-fluorophenyl)boronic acid 

Downstream Products

• 474334-52-6 (E)-3-(3-Cyano-4-fluoro-phenyl)-2-fluoro-but-2-enoic acid ethyl ester 
• 1095275-25-4 5-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-2-fluorobenzonitrile 
• 1095275-36-7 5-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl)-2-(1H-1,2,4-triazol-1-yl) benzonitrile 
• 1330021-26-5 5-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-[1,2,4]triazol-1-yl-benzonitrile 
• 1095275-37-8 5-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-fluoro-benzonitrile 
• 1266520-43-7 ethyl 5-bromo-4-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylate 
• 1266520-44-8 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid 
• 1266520-47-1 5-(3-chlorophenyl)-4-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid 
• 1266520-50-6 4-(3-cyano-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid 
• 1266520-51-7 4-(3-cyano-4-fluorophenyl)-5-(3-cyanophenyl)-1,3-thiazole-2-carboxylic acid 

Relevant articles and documents

Development and Molecular Understanding of a Pd-Catalyzed Cyanation of Aryl Boronic Acids Enabled by High-Throughput Experimentation and Data Analysis

A synthetic method for the palladium-catalyzed cyanation of aryl boronic acids using bench stable and non-toxic N-cyanosuccinimide has been developed. High-throughput experimentation facilitated the screen of 90 different ligands and the resultant statistical data analysis identified that ligand σ-donation, π-acidity and sterics are key drivers that govern yield. Categorization into three ligand groups – monophosphines, bisphosphines and miscellaneous – was performed before the analysis. For the monophosphines, the yield of the reaction increases for strong σ-donating, weak π-accepting ligands, with flexible pendant substituents. For the bisphosphines, the yield predominantly correlates with ligand lability. The applicability of the designed reaction to a wider substrate scope was investigated, showing good functional group tolerance in particular with boronic acids bearing electron-withdrawing substituents. This work outlines the development of a novel reaction, coupled with a fast and efficient workflow to gain understanding of the optimal ligand properties for the design of improved palladium cross-coupling catalysts.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kirl.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF

The present invention relates to novel substituted furancarboxamides, methods for their production, their use for the treatment and/or prevention of diseases, as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially retroviral diseases, in humans and/or animals.