28831-29-0

Basic information

• Product Name: Acetic acid, [[3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-quinazolinyl]thio]-, methyl ester
• CAS NO: 28831-29-0
• Molecular Formula: C18H16N2O4S
• Molecular Weight: 356.402
• Mol File: 28831-29-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetic acid, [[3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-quinazolinyl]thio]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [[3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-quinazolinyl]thio]-, methyl ester(28831-29-0)
• EPA Substance Registry System: Acetic acid, [[3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-quinazolinyl]thio]-, methyl ester(28831-29-0)

Safety Data

• Hazardous Substances Data: 28831-29-0(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 104-94-9 4-methoxy-aniline 
• 96-32-2 bromoacetic acid methyl ester 
• 1031-88-5 2-sulfhydryl-3-(4-methoxyphenyl)-quinazolin-4(3H)-one 
• 96-34-4 methyl chloroacetate 
• 1031-88-5 3‐(4‐methoxyphenyl)‐2‐thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one 
• 43009-18-3 4-methoxyphenyl dithiocarbamic acid triethylammonium 

Downstream Products

• 1046-12-4 2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetic acid 
• 1638842-86-0 methyl 1-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetyl)pyrrolidine-2-carboxylate 
• 1638842-85-9 methyl 3-hydroxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetamido)butanoate 
• 1638842-84-8 methyl 2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetamido)-4-methylpentanoate 
• 1638842-83-7 methyl 3-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetamido)propanoate 
• 1638842-82-6 methyl 3-hydroxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetamido)propanoate 
• 1638842-81-5 methyl 2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetamido)propanoate 
• 1638842-80-4 methyl 2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate 
• 193826-40-3 2-((3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazoline-2-yl)thio)acetohydrazide 

Relevant articles and documents

Design and synthesis of new benzylidene-quinazolinone hybrids as potential anti-diabetic agents: In vitro α-glucosidase inhibition, and docking studies

A novel series of benzylidene-quinazolinone hybrids 8a,b and 10a-n were designed, synthesized, and evaluated for their in vitro α-glucosidase inhibitory effect aiming to discover efficient anti-diabetic agents. The synthesized compounds were assessed for their in vivo anti-hyperglycemic activities against STZ-induced hyperglycemic rats. Five compounds (10m, 10f, 10c, 10d and 8b) demonstrated potent activities with percent reduction in blood glucose levels of 43.07, 40.14, 39.83, 37.04 and 36.16, respectively. The most active members were further evaluated in vitro for their α-glucosidase inhibitory binding affinities. Among them, Compound 10m containing 4-hydroxybenzylidene moiety and compound 10f with 4-chlorobenzylidene moiety connected to the acetohydrazide demonstrated the most potent inhibitory activities towards α-glucosidase with IC50 values of 561 and 610 μM, respectively. Molecular docking study was performed in order to understand the molecular interactions between the molecule and enzyme.

Synthesis of some New 2-Thioxoquinazolin-4-ones

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