28924-18-7Relevant articles and documents
Terbutaline sulfate intermediate, preparation method thereof and method for preparing terbutaline sulfate by using same (by machine translation)
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Paragraph 0089; 0090, (2020/08/22)
The invention discloses a terbutaline sulfate intermediate and a preparation method thereof as well as a method for preparing terbutaline sulfate by using the same, and belongs to the technical field of pharmaceutical chemistry. The invention provides a novel method for preparing terbutaline sulfate which is mild in reaction condition, high in yield and environmentally friendly, and firstly provides a terbutaline sulfate intermediate shown as a formula I; then, a catalyst is used as 10% Pd/C, an alcohol aqueous solution is used as a solvent, and hydrogenation is reduced to obtain the terbutaline II sulfate. The free base hydrochloride or hydrobromide of the formula I is converted into the formula I before hydrogenation reduction, then the terbutaline sulfate is directly obtained after hydrogenation reduction, and the advantages of mild reaction conditions, high product yield, high purity, low production cost and the like are avoided. (by machine translation)
Preparation method of high-purity injection-grade terbutaline sulfate
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Paragraph 0017; 0018; 0022; 0023; 0027; 0028, (2019/02/19)
The invention provides a preparation method of high-purity injection-grade terbutaline sulfate. The preparation method is characterized in that 3,5-dibenzyloxyacetophenone is adopted as a raw material, a bromination reaction, a substitution reaction, carbonyl reduction and hydrogenation reduction are conducted, salifying with sulfuric acid is conducted, and the terbutaline sulfate is obtained. A synthetic route is shown in the description.
Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
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Page/Page column 35; 55, (2016/12/07)
This disclosure concerns the discovery of the use of fenoterol and (R,R)- and (R,S)-fenoterol analogs for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2-adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analog or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject.