290297-24-4

Basic information

• Product Name: 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine
• Synonyms: 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine
• CAS NO: 290297-24-4
• Molecular Weight: 282.388
• Mol File: 290297-24-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine(290297-24-4)
• EPA Substance Registry System: 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine(290297-24-4)

Safety Data

• Hazardous Substances Data: 290297-24-4(Hazardous Substances Data)

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 1671094-96-4 1-(4-methoxy-5-nitropyridin-2-yl)-4-methylpiperazine 
• 109-01-3 1-methyl-piperazine 
• 607373-83-1 2-chloro-4-methoxy-5-nitro-pyridine 
• 607373-82-0 2-hydroxy-4-methoxy-5-nitro pyridine 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 342417-01-0 4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide 
• 342417-00-9 6-chloro-4-(o-tolyl)nicotinamide 
• 342416-99-3 6-chloro-4-o-tolyl-nicotinic acid 
• 33872-80-9 o-tolyl magnesium chloride 
• 55403-34-4 1-methyl-4-(5-nitropyridin-2-yl)piperazine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 290297-22-2 N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide 
• 290297-21-1 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-propionamide 

Downstream Products

• 290297-25-5 methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine 
• 290297-26-6 netupitant 

Relevant articles and documents

METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF

Methods are disclosed for the preparation of netupitant and pharmaceutically acceptable salts thereof which are novel, easily reproducible, environmentally safe and cost effective. The methods may employ inexpensive starting materials and the preparation processes for intermediates are simple and highly reproducible. Novel intermediates for the preparation of netupitant and pharmaceutically acceptable salts thereof are also disclosed. Amorphous netupitant and methods of making same are disclosed.

Substituted 4-phenyl pyridines having anti-emetic effect

Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):

4-phenyl-pyridine derivatives

The compounds of the related invention are related to 4-phenyl-pyridine derivatives connected by a bridge containing oxygen or nitrogen to a phenyl derivative.