290297-25-5 Usage
Description
3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)is a chemical compound with a complex structure, characterized by its unique arrangement of pyridine, methyl, phenyl, and piperazinyl groups. 3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)serves as a crucial intermediate in the synthesis of various pharmaceuticals and has potential applications in the development of novel drugs.
Uses
Used in Pharmaceutical Industry:
3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)is used as a reactant in the synthesis of NK1 receptor antagonists. These antagonists are important for the development of medications targeting conditions such as migraine, anxiety, and depression. 3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)plays a vital role in the 1,4-Grignard addition/oxidation sequence to 6-chloronicotinic acid and its derivatives, which are key steps in the production of these therapeutic agents.
Used in Chemical Research:
In addition to its pharmaceutical applications, 3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)may also be utilized in chemical research for the exploration of new synthetic pathways and the development of novel compounds with potential applications in various fields, such as materials science, agrochemistry, and environmental science. Its unique structure and reactivity make it a valuable tool for researchers in the chemical community.
Check Digit Verification of cas no
The CAS Registry Mumber 290297-25-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,0,2,9 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 290297-25:
(8*2)+(7*9)+(6*0)+(5*2)+(4*9)+(3*7)+(2*2)+(1*5)=155
155 % 10 = 5
So 290297-25-5 is a valid CAS Registry Number.
290297-25-5Relevant articles and documents
NK1 receptor-targeting antagonist and application of same to chemotherapy-induced nausea and vomiting
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, (2019/03/15)
The invention relates to a NK1 receptor-targeting antagonist and application of the same to chemotherapy-induced nausea and vomiting, belonging to the technical field of adjuvant therapeutics for tumor chemotherapy. The invention provides a compound as shown in a formula I which is described in the specification, or a racemate, stereoisomer, tautomer, isotopic label, oxynitride or pharmaceutically-acceptable salt thereof. The invention also provides a preparation method for the compound, a pharmaceutical compositions and the application of the compound or the racemate, stereoisomer, tautomer,isotopic label, oxynitride or pharmaceutically-acceptable salt thereof.
METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF
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, (2015/11/25)
Methods are disclosed for the preparation of netupitant and pharmaceutically acceptable salts thereof which are novel, easily reproducible, environmentally safe and cost effective. The methods may employ inexpensive starting materials and the preparation processes for intermediates are simple and highly reproducible. Novel intermediates for the preparation of netupitant and pharmaceutically acceptable salts thereof are also disclosed. Amorphous netupitant and methods of making same are disclosed.
Substituted 4-phenyl pyridines having anti-emetic effect
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, (2013/05/08)
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):