290297-23-3

Basic information

• Product Name: 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide
• Synonyms: 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide
• CAS NO: 290297-23-3
• Molecular Weight: 366.506
• Mol File: 290297-23-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide(290297-23-3)
• EPA Substance Registry System: 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide(290297-23-3)

Safety Data

• Hazardous Substances Data: 290297-23-3(Hazardous Substances Data)

Upstream product

• 55403-34-4 1-methyl-4-(5-nitropyridin-2-yl)piperazine 
• 290297-22-2 N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide 
• 16419-60-6 2-Methylphenylboronic acid 
• 4548-45-2 2-chloro-5-nitropyridine 
• 109-01-3 1-methyl-piperazine 
• 290297-21-1 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-propionamide 
• 55403-35-5 6-(4-methyl-1-piperazinyl)-3-pyridinylamine 

Downstream Products

• 290297-26-6 netupitant 
• 290297-25-5 methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine 
• 290297-24-4 6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl-amine 

Relevant articles and documents

Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists

The discovery of a novel, achiral pyridine class of potent and orally active neurokinin-1 (NK1) receptor antagonists is described. The evaluation of this class is briefly outlined, leading to the identification of netupitant 21 and befetupitant 29, two new proprietary chemical entities with high affinity and excellent CNS penetration.