290366-79-9 Usage
Description
(R)-(-)-3-(4-chloro-phenyl)-4-nitro-butyric acid is a chiral chemical compound with the molecular formula C10H10ClNO4. It is a nitroalkanoic acid derivative featuring a 4-chloro-phenyl group attached to the third carbon of the butyric acid chain. The (R)-(-) enantiomer is the active form of this compound, which is significant in research and pharmaceutical development.
Uses
Used in Pharmaceutical Development:
(R)-(-)-3-(4-chloro-phenyl)-4-nitro-butyric acid is used as a research compound for studying GABA receptors and neurotransmitter systems. Its activity in this area makes it a valuable tool in the development of pharmaceuticals targeting neurological disorders.
Used in Neurological Disorder Treatment:
In the medical field, (R)-(-)-3-(4-chloro-phenyl)-4-nitro-butyric acid is used as a potential therapeutic agent for the treatment of neurological disorders. Its interaction with GABA receptors and neurotransmitter systems offers promise in managing such conditions.
Used as a Building Block in Synthesis:
(R)-(-)-3-(4-chloro-phenyl)-4-nitro-butyric acid is also utilized as a building block in the synthesis of other pharmaceutical compounds. Its unique structure and functional groups make it a versatile component in the creation of new molecules with potential medicinal properties.
Used in Research and Development:
In the research industry, (R)-(-)-3-(4-chloro-phenyl)-4-nitro-butyric acid is used as a key compound for exploring the mechanisms of GABA receptors and neurotransmission. This helps in understanding the underlying causes of neurological disorders and aids in the development of novel treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 290366-79-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,0,3,6 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 290366-79:
(8*2)+(7*9)+(6*0)+(5*3)+(4*6)+(3*6)+(2*7)+(1*9)=159
159 % 10 = 9
So 290366-79-9 is a valid CAS Registry Number.
290366-79-9Relevant articles and documents
Squaramide-Catalyzed Michael Addition as a Key Step for the Direct Synthesis of GABAergic Drugs
Veverková, Eva,Bilka, Stanislav,Baran, Rastislav,?ebesta, Radovan
, p. 1474 - 1482 (2016/05/24)
Enantioselective organocatalytic Michael additions serve as the key step in syntheses of chiral drugs based on γ-aminobutyric acid. The applicability of various squaramide catalysts for these Michael-type reactions has been assessed. Very good results in
Regio- and enantioselective palladium-catalyzed allylic alkylation of nitromethane with monosubstituted allyl substrates: Synthesis of (R)-rolipram and (R)-baclofen
Yang, Xiao-Fei,Ding, Chang-Hua,Li, Xiao-Hui,Huang, Jian-Qiang,Hou, Xue-Long,Dai, Li-Xin,Wang, Pin-Jie
, p. 8980 - 8985 (2013/01/15)
The Pd-catalyzed asymmetric allylic alkylation (AAA) reaction of nitromethane with monosubstituted allyl substrates was realized for the first time to provide corresponding products in high yields with excellent regio- and enantioselectivities. The protocol was applied to the enantioselective synthesis of (R)-baclofen and (R)-rolipram.
Catalytic asymmetric conjugate addition of nitroalkanes to 4-nitro5-styrylisoxazoles
Baschieri, Andrea,Bernardi, Luca,Ricci, Alfredo,Suresh, Surisetti,Adamo, Mauro F. A.
supporting information; experimental part, p. 9342 - 9345 (2010/03/24)
(Chemical equation presented) Nitro versus nitro: 4-Nitro-5- styrylisoxazoles were used as masked α,β-unsaturated carboxylic acids in the titled catalytic asymmetric transformation. The 4-nitroisoxazole core acts as an activator of the conjugated alkene and a latent carboxylate functionality. The reaction proceeded with 5 mol% of a readily prepared phasetransfer catalyst at room temperature with remarkable diastereo- and enantioselectivity (see scheme).
