2923-16-2 Usage
Description
Potassium trifluoroacetate is a white crystalline powder that serves as a reagent in the preparation of aryl trifluoromethyl sulfides. It is synthesized by heating diaryl disulfide, and its chemical properties make it a valuable compound in various applications.
Uses
Used in Chemical Synthesis:
Potassium trifluoroacetate is used as a reagent for the preparation of aryl trifluoromethyl sulfides, which are important intermediates in the synthesis of various organic compounds. The application reason is its ability to facilitate the formation of these intermediates through a heating process with diaryl disulfide.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, potassium trifluoroacetate is used as a building block for the synthesis of various drug molecules. Its application reason is its versatility in chemical reactions, allowing for the creation of a wide range of pharmaceutical compounds.
Used in Material Science:
Potassium trifluoroacetate is also utilized in material science for the development of novel materials with specific properties. The application reason is its ability to participate in various chemical reactions, leading to the formation of materials with unique characteristics.
Flammability and Explosibility
Nonflammable
Purification Methods
To purify it, dissolve the salt in trifluoroacetic acid with ca 2% of trifluoroacetic anhydride, filter it and evaporate it carefully to dryness (avoid over heating), and finally dry it in a vacuum at 100o. It can be recrystallised from trifluoroacetic acid (solubility in the acid is ca 50.1%). [Simons & Lorentzen J Am Chem Soc 74 4746 1952, Hara & Cady J Am Chem Soc 76 4285 1954, Watt & Muga J Inorg Nucl Chem 9 166 1959, Beilstein 2 IV 458.]
Check Digit Verification of cas no
The CAS Registry Mumber 2923-16-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,2 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2923-16:
(6*2)+(5*9)+(4*2)+(3*3)+(2*1)+(1*6)=82
82 % 10 = 2
So 2923-16-2 is a valid CAS Registry Number.
InChI:InChI=1/C2HF3O2.K/c3-2(4,5)1(6)7;/h(H,6,7);/q;+1/p-1
2923-16-2Relevant articles and documents
Alkali metal trifluoroacetates for the nucleophilic trifluoromethylation of fullerenes
Bogdanov, Viktor P.,Dmitrieva, Veronika A.,Ioutsi, Vitaliy A.,Belov, Nikita M.,Goryunkov, Alexey A.
, (2019)
Fullerene C60 readily reacts with potassium and cesium trifluoroacetates yielding C60(CF3)–M+ salts, and subsequent acid hydrolysis gives ortho-C60(CF3)H. The reaction rate and the probability of the alternative reaction pathways strongly depend on the particular metal cation. Thus, the reactivity increases in the order Li 2- rather than CF3-functionalization of the fullerene, in good accordance with the hard/soft acids and bases theory. The nucleophilic trifluoromethylation is found to be applicable to other pristine fullerenes like C70 as well as to fullerene derivatives like p7mp-C70(CF3)10. It enables selective preparation of low trifluoromethylated fullerenes via regioselective consecutive trifluoromethylation under accurately controlled solution-phase conditions.
Recyclable Trifluoromethylation Reagents from Fluoroform
Geri, Jacob B.,Szymczak, Nathaniel K.
supporting information, p. 9811 - 9814 (2017/08/03)
We present a strategy to rationally prepare CF3- transfer reagents at ambient temperature from HCF3. We demonstrate that a highly reactive CF3- adduct can be synthesized from alkali metal hydride, HCF3, and borazine Lewis acids in quantitative yield at room temperature. These nucleophilic reagents transfer CF3- to substrates without additional chemical activation, and after CF3 transfer, the free borazine is quantitatively regenerated. These features enable syntheses of popular nucleophilic, radical, and electrophilic trifluoromethylation reagents with complete recycling of the borazine Lewis acid.
TEMPO mediated oxidation of fluorinated alcohols to carboxylic acids
Ignatowska, Jolanta,Shyshkov, Oleg,Zipplies, Tilman,Hintzer, Klaus,R?schenthaler, Gerd-Volker
experimental part, p. 35 - 40 (2012/09/21)
Fluorinated carboxylic acids (3a-f) have been prepared in good yield by oxidizing the corresponding alcohols (2a-f) in the presence of TEMPO (1) as catalyst, using oxidants like bleach and oxygen.