57830-49-6

Basic information

• Product Name: Pyridine, 2-[(trifluoromethyl)thio]-
• Synonyms: 2-Trifluormethylthiopyridin;2-pyridyl trifluoromethyl sulfide;2-trifluoromethylsulfanyl-pyridine;trifluoromethyl-2-pyridyl sulfide
• CAS NO: 57830-49-6
• Molecular Formula: C6H4F3NS
• Molecular Weight: 179.16300
• Mol File: 57830-49-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-[(trifluoromethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-[(trifluoromethyl)thio]-(57830-49-6)
• EPA Substance Registry System: Pyridine, 2-[(trifluoromethyl)thio]-(57830-49-6)

Safety Data

• Hazardous Substances Data: 57830-49-6(Hazardous Substances Data)

Upstream product

• 2127-03-9 2,2'-dipyridyldisulphide 
• 75-46-7 trifluoromethan 
• 109-04-6 2-bromo-pyridine 
• 1413732-47-4 (2,2'-bipyride-kN₁,kN₁')(1,1,1-trifluoromethanethiolato-kS)-copper 
• 2637-34-5 2-Sulfanylpyridine 
• 2926-29-6 Langlois reagent 
• 5029-67-4 2-iodopyridine 
• 2314-97-8 iodotrifluoromethane 
• 3872-23-9 Copper(I) trifluoromethanethiolate 
• 2923-16-2 potassium trifluoroacetate 
• 78840-45-6 2-(Bromo-difluoro-methylsulfanyl)-pyridine 
• 1121-30-8 1-hydroxy-2(1H)-pyridinethione 
• 407-25-0 trifluoroacetic anhydride 
• 356-42-3 2,2,3,3,3-pentafluoropropanoic anhydride 

Relevant articles and documents

Copper-Mediated Trifluoromethylthiolation of Heteroaryl Bromides

An efficient protocol for the copper-mediated trifluoromethylthiolation of heteroaryl bromides has been achieved using the copper complex (bpy)Cu(SCF3) as trifluoromethylthiolating reagent. This procedure provides a straightforward synthetic method for heteroaryl trifluoromethyl sulfides from readily available, simple starting materials. The reaction demonstrates a broad substrate scope and tolerates a wide array of functional groups, including nitrile, ester, chloro, nitro, or methoxy substituents.

Trifluoromethylation of thiophenols and thiols with sodium trifluoromethanesulfinate and iodine pentoxide

A selective and facile trifluoromethylation process for a wide range of thiophenols and thiols under metal free conditions has been developed using two simple and safe solids, sodium trifluoro-methanesulfinate and iodine pentoxide, via the radical process.

Copper-catalyzed synthesis of aryl and alkyl trifluoromethyl sulfides using CF3SiMe3and Na2S2O3as -SCF3source

A universal and efficient Cu(I)-catalyzed synthesis of aryl and alkyl trifluoromethyl sulfides has been developed. In this catalytic system, S-aryl or S-alkyl sulfothioate (I or II) proved to be the key intermediate. Substrates bearing groups of I, Br, Cl, OTs, and OMs on the aryl carbon and no matter electron-withdrawing and electron-donating substitutions on the aromatic ring could afford good to excellent yields.