29329-71-3

Basic information

• Product Name: 1-Hydroxyethanediphosphonic acid sodium salt
• Synonyms: (1-hydroxyethylidene)bisphosphonic acid, sodium salt;Phosphonic acid, (1-hydroxyethylidene)bis-, sodium salt;(1-Hydroxyethyliden)bisphosphonsure, Natriumsalz;1-Hydroxyethanediphosphonic acid, sodium salt;Hydroxyethylidene diphosphonic acid, sodium salt;1-Hydroxyethane-1,1-diphosphonic acid sodium salt;MONO-SODIUM SALT OF 1-HYDROXY ETHYLIDENE-1,1-DIPHOSPHONIC ACID;sodium 1-hydroxyethylidene diphosphonate
• CAS NO: 29329-71-3
• Molecular Formula: C₂H₄O₇P₂*4Na
• Molecular Weight: 293.96
• EINECS: 249-559-4
• Mol File: 29329-71-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 578.8oC at 760 mmHg
• Flash Point: 303.8oC
• Appearance: /
• Vapor Pressure: 8.34E-16mmHg at 25°C
• CAS DataBase Reference: 1-Hydroxyethanediphosphonic acid sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxyethanediphosphonic acid sodium salt(29329-71-3)
• EPA Substance Registry System: 1-Hydroxyethanediphosphonic acid sodium salt(29329-71-3)

Safety Data

• Hazardous Substances Data: 29329-71-3(Hazardous Substances Data)

Usage

General Description

1-Hydroxyethanediphosphonic acid sodium salt, also known as HEDP-Na, is a sodium salt of a phosphonic acid commonly used as a sequestering agent, scale inhibitor, and corrosion inhibitor in various industrial applications. It is effective in controlling the deposition of scale and preventing corrosion in water treatment processes, such as cooling systems, boilers, and oil field operations. HEDP-Na is also utilized in the textile industry as a dye-fixing agent and as a stabilizer in bleaching agents. Additionally, it is used in personal care products and detergents as a chelating agent. Its stability over a wide pH range, excellent sequestering properties, and low toxicity make it a valuable chemical for various industrial and commercial applications.

InChI:InChI=1/C2H8O7P2.Na/c1-2(3,10(4,5)6)11(7,8)9;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 2809-21-4 1-hydroxyethylene-(1,1-diphosphonic acid) 
• 106-89-8 epichlorohydrin 
• 141-43-5 ethanolamine 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 30148-50-6 bis(trimethylsilyl)phosphonite 
• 6838-42-2 acetylphosphonic acid di(trimethylsilyl) ester 

Downstream Products

• 34162-79-3 vinylidene-1,1-diphosphonic acid 

Relevant articles and documents

One-pot synthesis of phosphinylphosphonate derivatives and their anti-tumor evaluations

This paper reports on the synthesis of new hydroxymethylene-(phosphinyl)phosphonates (HMPPs). A methodology has been developed to propose an optimized one-pot procedure without any intermediate purifications. Various aliphatic and (hetero)aromatic HMPPs were synthesized in good to excellent yields (53–98%) and the influence of electron withdrawing/donating group substitution on aromatic substrates was studied. In addition, the one-pot synthesis of HMPP was monitored by31P NMR spectroscopy, allowing effective control of the end of the reaction and identification of all phosphorylated intermediate species, which enabled us to propose a reaction mechanism. Optimized experimental conditions were applied to the preparation of biological relevant aminoalkyl-HMPPs. A preliminary study of the complexation to hydroxyapatite (bone matrix) was carried out in order to verify its lower affinity towards bone compared to bisphosphonate molecules. Moreover, in vitro anti-tumor activity study revealed encouraging antiproliferative activities on three human cancer cell lines (breast, pancreas and lung).

Optimized synthesis of etidronate

The synthesis of Etidronate (as the disodium salt) by the reaction of acetic acid with phosphorus trichloride/phosphorus acid in methanesulfonic acid was studied and optimized. We showed that it is enough to use 3.2 equivalents of the phosphorus trichlori

Aminohydroxypropane esters of hydroxyethylidenebisphosphoric acid.

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