293731-49-4

Basic information

• Product Name: benzyl 2-(4-fluorophenyl)ethanoate
• Synonyms: benzyl 2-(4-fluorophenyl)ethanoate
• CAS NO: 293731-49-4
• Molecular Weight: 244.265
• Mol File: 293731-49-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: benzyl 2-(4-fluorophenyl)ethanoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-(4-fluorophenyl)ethanoate(293731-49-4)
• EPA Substance Registry System: benzyl 2-(4-fluorophenyl)ethanoate(293731-49-4)

Safety Data

• Hazardous Substances Data: 293731-49-4(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 100-51-6 benzyl alcohol 
• 702-11-4 4-fluoro-N,N-dimethylbenzylamine 
• 405-50-5 p-Fluorophenylacetic acid 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 1090480-39-9 N-(benzyloxy)-2-(4-fluorophenyl)acetamide 
• 108-88-3 toluene 
• 100-39-0 benzyl bromide 

Downstream Products

• 293731-64-3 (αS,3'R)-4',4'-dimethyl-γ-butyrolacton-3'-yl 2-(4-fluorophenyl)-3-phthalimidopropanoate 
• 267001-10-5 (αR,3'R)-4',4'-dimethyl-γ-butyrolacton-3'-yl 2-(4-fluorophenyl)-3-phthalimidopropanoate 
• 293731-59-6 (RS)-3-phthalimido-2-(4-fluorophenyl)propanoic acid chloride 
• 293731-55-2 (RS)-2-(4-fluorophenyl)-3-phthalimidopropanoic acid 
• 293731-51-8 (RS)-benzyl 2-(4-fluorophenyl)-3-phthalimidopropanoate 
• 512176-77-1 benzyl 2-benzoyl-2-(4-fluorophenyl)ethanoate 
• 512176-89-5 benzyl 2-benzoyl-2-(4-fluorophenyl)propanoate 

Relevant articles and documents

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.

Direct conversion of N -alkoxyamides to carboxylic esters through tandem nbs-mediated oxidative homocoupling and thermal denitrogenation

Treatment of N-alkoxyamides with NBS in toluene was found to conveniently afford the corresponding carboxylic esters, including those bearing a bulky or long-chain substituent, in satisfactory to excellent yields. This approach not only represents a convenient and economic approach to a direct transformation of an alkoxyamide moiety into the carboxylic ester functional group, via oxidative homocoupling and the subsequent thermal denitrogenation, but also facilitates the synthesis of sterically hindered carboxylic esters.

Asymmetric synthesis of (S)-β2-homoarylglycines

The synthesis of racemic N-phthalyl β2-homoarylglycines 5 and their asymmetric transformation have been investigated. The key step is the stereoselective addition of the (R)-pantolactone to the corresponding prochiral ketene 7.