702-11-4

Basic information

• Product Name: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-
• Synonyms: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-
• CAS NO: 702-11-4
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.1966832
• Mol File: 702-11-4.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-(702-11-4)
• EPA Substance Registry System: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-(702-11-4)

Safety Data

• Hazardous Substances Data: 702-11-4(Hazardous Substances Data)

Usage

General Description

BenzeneMethanaMine, 4-fluoro-N,N-diMethyl- is a chemical compound with the molecular formula C9H11FN. It is commonly known as 4-fluoro-N,N-diMethylbenzylamine or 4-FDMA and is a derivative of amphetamine. BenzeneMethanaMine, 4-fluoro-N,N-diMethyl- is often used in research settings as a reference standard for forensic and toxicology laboratories. It is known for its psychoactive and stimulant effects and has been identified as a potential designer drug, although its legal status may vary depending on the jurisdiction. 4-FDMA is often sold as a white powder or in tablet form and can be ingested, snorted, or injected. Its effects on the human body include increased energy, alertness, and euphoria, but it can also have negative side effects and be addictive.

Upstream product

• 140-75-0 para-fluorobenzylamine 
• 922142-70-9 (4-fluorobenzyl)dimethylamine N-oxide 
• 506-59-2 N,N-dimethylammonium chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 
• 124-40-3 dimethyl amine 
• 459-46-1 4-Fluorobenzyl bromide 
• 6274-57-3 (4-bromobenzyl)dimethylamine 
• 24167-56-4 N,N-dimethyl-4-fluorobenzamide 
• 67-56-1 methanol 
• 1194-02-1 4-fluorobenzonitrile 
• 50-00-0 formaldehyd 
• 405-66-3 (4-Fluoro-benzyl)-methyl-amine 
• 159979-96-1 4-fluorobenzyl azide 

Downstream Products

• 125889-26-1 4-fluoro-3-trimethylsilyl-N,N-dimethyl-benzylamine 
• 125889-27-2 4-fluoro-2-trimethylsilyl-N,N-dimethylbenzylamine 
• 115911-28-9 3-(4-fluorobenzyl)pyridine-2,6-diamine 
• 1192229-93-8 4-fluorobenzyldimethylamine borane 
• 1258839-95-0 ethyl 2-((dimethylamino)methyl)-5-fluorobenzoate 
• 243145-83-7 2-[(4-fluorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 352-32-9 p-fluorotoluene 
• 293731-49-4 benzyl 2-(4-fluorophenyl)ethanoate 
• 405-50-5 p-Fluorophenylacetic acid 
• 458-76-4 4,4'-difluorobibenzyl 
• 78974-45-5 1-fluoro-4-((phenylsulfonyl)methyl)benzene 
• 67751-25-1 1-dimethylamino-1,2-di(methoxycarbonyl)ethene 

Relevant articles and documents

Palladium-Catalyzed Reductive Aminocarbonylation of Benzylammonium Triflates with o-Nitrobenzaldehydes for the Synthesis of 3-Arylquinolin-2(1 H)-ones

A palladium-catalyzed straightforward procedure for the synthesis of 3-arylquinolin-2(1H)-ones has been developed. The synthesis proceeds through a palladium-catalyzed reductive aminocarbonylation reaction of benzylic ammonium triflates with o-nitrobenzaldehydes, and a wide range of 3-arylquinolin-2(1H)-ones was obtained in moderate to good yields with very good functional group compatibility.

Zirconium-hydride-catalyzed site-selective hydroboration of amides for the synthesis of amines: Mechanism, scope, and application

Developing mild and efficient catalytic methods for the selective synthesis of amines is a longstanding research objective. In this respect, catalytic deoxygenative amide reduction has proven to be promising but challenging, as this approach necessitates selective C–O bond cleavage. Herein, we report the selective hydroboration of primary, secondary, and tertiary amides at room temperature catalyzed by an earth-abundant-metal catalyst, Zr-H, for accessing diverse amines. Various readily reducible functional groups, such as esters, alkynes, and alkenes, were well tolerated. Furthermore, the methodology was extended to the synthesis of bio- and drug-derived amines. Detailed mechanistic studies revealed a reaction pathway entailing aldehyde and amido complex formation via an unusual C–N bond cleavage-reformation process, followed by C–O bond cleavage.

Cu2O-catalyzed C–S coupling of quaternary ammonium salts and sodium alkane-/arene-sulfinates

A new protocol for the synthesis of (enantioenriched) benzylic sulfones via the Cu2O-catalyzed C–S bond cross coupling of alkane-/arene-sulfinates and (enantioenriched) benzylic quaternary ammonium salts has been developed. The product benzylic sulfones were obtained in good to high yields (75–96%). Chiral arylmethyl sulfones with high enantiomeric excess (90–94% ee) were also synthesized in the presence of Cu2O and 1,1′-bis-(diphenylphosphino)ferrocene (dppf).