78974-45-5

Basic information

• Product Name: Benzene, 1-fluoro-4-[(phenylsulfonyl)methyl]-
• CAS NO: 78974-45-5
• Molecular Formula: C13H11FO2S
• Molecular Weight: 250.294
• Mol File: 78974-45-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzene, 1-fluoro-4-[(phenylsulfonyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-fluoro-4-[(phenylsulfonyl)methyl]-(78974-45-5)
• EPA Substance Registry System: Benzene, 1-fluoro-4-[(phenylsulfonyl)methyl]-(78974-45-5)

Safety Data

• Hazardous Substances Data: 78974-45-5(Hazardous Substances Data)

Upstream product

• 3112-85-4 methylphenylsulfonate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-56-3 4-fluorobenzylic alcohol 
• 873-55-2 sodium benzenesulfonate 
• 702-11-4 4-fluoro-N,N-dimethylbenzylamine 
• 459-46-1 4-Fluorobenzyl bromide 
• 351-66-6 1-[(phenylthio)methyl]-4-fluoro-benzene 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 405-50-5 p-Fluorophenylacetic acid 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 106492-30-2 (E)-1-fluoro-4-[2-(benzenesulfonyl)vinyl]benzene 
• 1609277-64-6 (4-fluorophenyl)(4-methylphenyl)methyl phenyl sulfone 
• 1609277-74-8 (4-fluorophenyl)(4-methoxyphenyl)(4-methylphenyl)methane 
• 705966-19-4 1-[(phenyl)sulfonyl]ethenyl-4-fluorobenzene 

Relevant articles and documents

Synthesis of Sulfones and Sulfonamides via Sulfinate Anions: Revisiting the Utility of Thiosulfonates

Simple and high-yielding strategies for the production of a variety of sulfones and sulfonamides, using thiosulfonates synthesized by copper-catalyzed aerobic dimerization, are reported. Although thiosulfonates are an old class of compound, practical methods for their synthesis and utilization have not been rigorously developed. In this study, we revisit the reactions of easily accessible thiosulfonates to form sulfinate anions. Because of the similar reactivity of thiosulfonates and metal sulfinates derived from toxic SO2, thiosulfinates are proposed to be stable, nontoxic alternatives to metal sulfinate salts.

Cu-mediated: vs. Cu-free selective borylation of aryl alkyl sulfones

A Cu-catalysed borylation of aryl alkyl sulfones was developed for the high yield synthesis of versatile arylboronic esters using a readily prepared NHC-Cu catalyst. In addition, the selective cleavage of either alkyl(C)-sulfonyl or aryl(C)-sulfonyl bonds

Base-controlled divergent synthesis of vinyl sulfones from (benzylsulfonyl)benzenes and paraformaldehyde

A tuneable metal-free protocol for the selective preparation of a-substituted vinyl sulfone and (E)-vinyl sulfone derivatives has been described. In this process, stable paraformaldehyde was used as the carbon source. The base played an important role in the selectivity control of transformations. More than 50 products were synthesized with excellent chemoselectivity and broad functional group tolerance.