351-66-6

Basic information

• Product Name: 4-FLUOROBENZYL PHENYL SULFIDE
• Synonyms: 4-FLUOROBENZYL PHENYL SULFIDE;4-FLUOROBENZYL PHENYL SULPHIDE;P-FLUOROBENZYL PHENYL SULPHIDE;4-Fluorobenzyl phenyl sulphide 97%;4-Fluorobenzylphenylsulphide97%;4-FLUOROBENZYL PHENYL SULFIDE 97%;P-FLUOROBENZYL PHENYL SULFIDE;1-Fluoro-4-[(phenylthio)methyl]benzene
• CAS NO: 351-66-6
• Molecular Formula: C₁₃H₁₁FS
• Molecular Weight: 218.29
• Mol File: 351-66-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 59 °C
• Boiling Point: 319.8°Cat760mmHg
• Flash Point: 147.2°C
• Appearance: /
• Density: 1.17g/cm³
• CAS DataBase Reference: 4-FLUOROBENZYL PHENYL SULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZYL PHENYL SULFIDE(351-66-6)
• EPA Substance Registry System: 4-FLUOROBENZYL PHENYL SULFIDE(351-66-6)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 24/25-36
• Hazardous Substances Data: 351-66-6(Hazardous Substances Data)

Usage

General Description

4-FLUOROBENZYL PHENYL SULFIDE is a chemical compound with the molecular formula C13H11FS. It is a thioether, which means it contains a sulfur atom bonded to two organic groups. 4-FLUOROBENZYL PHENYL SULFIDE is commonly used in organic synthesis and chemical research as a reagent or intermediate. It is known for its distinct odor and is typically stored and handled with care due to its potential health hazards. 4-FLUOROBENZYL PHENYL SULFIDE has various industrial and research applications, including in the production of pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 108-98-5 thiophenol 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 144084-37-7 O⁶-(4-fluorobenzyl)guanine 
• 930-69-8 sodium thiophenolate 
• 153706-08-2 1-fluoro-4-((phenylsulfinyl)methyl)benzene 
• 32691-93-3 α,α-dimethoxy-4-fluorotoluene 
• 882-33-7 diphenyldisulfane 
• 459-46-1 4-Fluorobenzyl bromide 
• 36719-71-8 1-phenyl-3,3-tetramethylenetriazene 
• 62-53-3 aniline 
• 100-68-5 methyl-phenyl-thioether 
• 702-11-4 4-fluoro-N,N-dimethylbenzylamine 

Downstream Products

• 78974-45-5 1-fluoro-4-((phenylsulfonyl)methyl)benzene 

Relevant articles and documents

Transition-metal-free decarboxylative thiolation of stable aliphatic carboxylates

A transition-metal-free decarboxylative thiolation protocol is reported in which primary, secondary, tertiary (hetero)aryl acetates and α-CN substituted acetates undergo the decarboxylative thiolation smoothly, to deliver a variety of functionalized aryl alkyl sulfides in moderate to excellent yields. Aryl diselenides are also amenable substrates for construction of C-Se bonds under the simple and mild reaction conditions. Moreover, the protocol is successfully applied to the late-stage modification of pharmaceutical carboxylates with satisfactory chemoselectivity and functional-group compatibility. This journal is

Alkyl Sulfides as Promising Sulfur Sources: Metal-Free Synthesis of Aryl Alkyl Sulfides and Dialkyl Sulfides by Transalkylation of Simple Sulfides with Alkyl Halides

A site-selective metal-free dealkylative approach to synthesize aryl alkyl and symmetrical dialkyl sulfides has been developed. This procedure is convenient and has wide functional group tolerance giving rise to sulfides carrying various alkyl chains from simple alkyl sulfides and alkyl halides in good to excellent yields. This transalkylation proceeds by an ionic mechanism via sulfonium intermediates and it was proposed that dimethylacetamide (DMAC) may participate in part to promote the reaction.

Sulfide synthesis through copper-catalyzed C-S bond formation under biomolecule-compatible conditions

We report here an efficient and mild method for constructing C-S bonds. The reactions were carried out with Na2S2O3 as a sulfurating reagent, CuSO4 as a catalyst, and water as solvent without any surfactant. The products were achieved in moderate to excellent yields at room temperature under air. Notably, this reaction is compatible with various biomolecules including amino acids, oligosaccharides, nucleosides, proteins, and cell lysates. This journal is