2942-23-6

Basic information

• Product Name: 2,7-Dichlorobenzothiazole
• Synonyms: 2,7-DICHLORO BENZOTHIAZOLE;Benzothiazole, 2,7-dichloro- (7CI,8CI,9CI);2,7-Dichlorobenzo[d]thiazole;2,7-Dichlor-benzthiazol;2,7-Dichloro-1,3-benzothiazole
• CAS NO: 2942-23-6
• Molecular Formula: C₇H₃Cl₂NS
• Molecular Weight: 204.08
• Product Categories: BENZOTHIAZOLE
• Mol File: 2942-23-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 286.8 °C at 760 mmHg
• Flash Point: 127.2 °C
• Appearance: /
• Density: 1.567 g/cm³
• Vapor Pressure: 0.00446mmHg at 25°C
• Refractive Index: 1.701
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.49±0.30(Predicted)
• CAS DataBase Reference: 2,7-Dichlorobenzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-Dichlorobenzothiazole(2942-23-6)
• EPA Substance Registry System: 2,7-Dichlorobenzothiazole(2942-23-6)

Safety Data

• Hazardous Substances Data: 2942-23-6(Hazardous Substances Data)

Usage

General Description

2,7-Dichlorobenzothiazole is a chemical compound that is commonly used as an industrial chemical intermediate in the production of rubber and rubber products. It is a white to yellowish crystal with a slightly sweet odor, and it is insoluble in water but soluble in organic solvents. This chemical is known for its ability to accelerate the vulcanization of rubber, making it an important ingredient in the production of tires, hoses, and conveyor belts. However, 2,7-Dichlorobenzothiazole is also considered to be toxic to aquatic organisms and may cause skin and eye irritation, so proper safety precautions should be taken when handling and using this compound.

InChI:InChI=1/C7H3Cl2NS/c8-4-2-1-3-5-6(4)11-7(9)10-5/h1-3H

Upstream product

• 1849-73-6 2-mercapto-7-chlorobenzothiazole 
• 3209-22-1 1,2-Dichloro-3-nitrobenzene 
• 534-18-9 sodium trithiocarbonate 
• 608-27-5 2,3-dichloroaniline 
• 2106-04-9 3-chloro-2-fluoroaniline 

Downstream Products

• 70200-88-3 2,7-Dichlor-4-nitro-benzthiazol 
• 315227-28-2 C₁₃H₆Cl₂N₂O₂S₂ 
• 70200-94-1 2,7-Dichlor-6-amino-benzthiazol 
• 1095537-55-5 7-chloro-N-(2,6-dimethylphenyl)benzo[d]thiazol-2-amine 

Relevant articles and documents

Water-Promoted Chlorination of 2-Mercaptobenzothiazoles

Substituted benzothiazoles play an important role in medicinal chemistry due to their pharmacological properties. Their 2-substituted derivatives are often prepared from 2-chlorobenzothiazoles, which in turn can be synthesized from the 2-mercapto precursor using sulfuryl chloride. In practice, this seemingly straightforward and widely used reaction can be impeded by poor reproducibility and low reaction yields. In this communication, we report that the simple addition of water to the reaction leads to remarkable improvements in reaction efficiency. We attribute this effect to the formation of acid through partial hydrolysis of sulfuryl chloride. This hypothesis is supported by the observation that improved yields were also obtained in the presence of some anhydrous acidic additives. The simple combination of sulfuryl chloride and water reproducibly provides excellent yields for a range of chlorinated products.

Therapeutic modulation of PPARgamma activity

Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.